Tags

Type your tag names separated by a space and hit enter

COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest.
Elife. 2021 02 23; 10E

Abstract

COVID-19 CG (covidcg.org) is an open resource for tracking SARS-CoV-2 single-nucleotide variations (SNVs), lineages, and clades using the virus genomes on the GISAID database while filtering by location, date, gene, and mutation of interest. COVID-19 CG provides significant time, labor, and cost-saving utility to projects on SARS-CoV-2 transmission, evolution, diagnostics, therapeutics, vaccines, and intervention tracking. Here, we describe case studies in which users can interrogate (1) SNVs in the SARS-CoV-2 spike receptor binding domain (RBD) across different geographical regions to inform the design and testing of therapeutics, (2) SNVs that may impact the sensitivity of commonly used diagnostic primers, and (3) the emergence of a dominant lineage harboring an S477N RBD mutation in Australia in 2020. To accelerate COVID-19 efforts, COVID-19 CG will be upgraded with new features for users to rapidly pinpoint mutations as the virus evolves throughout the pandemic and in response to therapeutic and public health interventions.

Authors+Show Affiliations

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.Independent web designer, Cambridge, United States.Department of Zoology & Biodiversity Research Centre, the University of British Columbia, Vancouver, Canada. Fusion Genomics Corporation, Burnaby, Canada.Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33620031

Citation

Chen, Albert Tian, et al. "COVID-19 CG Enables SARS-CoV-2 Mutation and Lineage Tracking By Locations and Dates of Interest." ELife, vol. 10, 2021.
Chen AT, Altschuler K, Zhan SH, et al. COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest. Elife. 2021;10.
Chen, A. T., Altschuler, K., Zhan, S. H., Chan, Y. A., & Deverman, B. E. (2021). COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest. ELife, 10. https://doi.org/10.7554/eLife.63409
Chen AT, et al. COVID-19 CG Enables SARS-CoV-2 Mutation and Lineage Tracking By Locations and Dates of Interest. Elife. 2021 02 23;10 PubMed PMID: 33620031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest. AU - Chen,Albert Tian, AU - Altschuler,Kevin, AU - Zhan,Shing Hei, AU - Chan,Yujia Alina, AU - Deverman,Benjamin E, Y1 - 2021/02/23/ PY - 2020/09/24/received PY - 2021/01/22/accepted PY - 2021/2/23/entrez PY - 2021/2/24/pubmed PY - 2021/3/9/medline KW - COVID-19 KW - SARS-CoV-2 KW - browser KW - epidemiology KW - evolutionary biology KW - global health KW - mutation tracking KW - pandemic KW - resource KW - virus JF - eLife JO - Elife VL - 10 N2 - COVID-19 CG (covidcg.org) is an open resource for tracking SARS-CoV-2 single-nucleotide variations (SNVs), lineages, and clades using the virus genomes on the GISAID database while filtering by location, date, gene, and mutation of interest. COVID-19 CG provides significant time, labor, and cost-saving utility to projects on SARS-CoV-2 transmission, evolution, diagnostics, therapeutics, vaccines, and intervention tracking. Here, we describe case studies in which users can interrogate (1) SNVs in the SARS-CoV-2 spike receptor binding domain (RBD) across different geographical regions to inform the design and testing of therapeutics, (2) SNVs that may impact the sensitivity of commonly used diagnostic primers, and (3) the emergence of a dominant lineage harboring an S477N RBD mutation in Australia in 2020. To accelerate COVID-19 efforts, COVID-19 CG will be upgraded with new features for users to rapidly pinpoint mutations as the virus evolves throughout the pandemic and in response to therapeutic and public health interventions. SN - 2050-084X UR - https://www.unboundmedicine.com/medline/citation/33620031/COVID_19_CG_enables_SARS_CoV_2_mutation_and_lineage_tracking_by_locations_and_dates_of_interest_ L2 - https://doi.org/10.7554/eLife.63409 DB - PRIME DP - Unbound Medicine ER -