Tags

Type your tag names separated by a space and hit enter

Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study.
BMC Infect Dis. 2021 Feb 24; 21(1):207.BI

Abstract

BACKGROUND

A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China.

METHODS

Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe).

RESULTS

Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05).

CONCLUSION

Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.

Authors+Show Affiliations

Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Department of Infectious Diseases, Baoji Central Hospital, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Department of Cardiovascular Medicine, Baoji Central Hospital, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China.Department of Infectious Diseases, Baoji Central Hospital, Baoji, 721008, Shaanxi, China.Department of Infectious Diseases, Baoji Central Hospital, Baoji, 721008, Shaanxi, China.Present Address: Department of Pulmonary and Critical Care Medicine, Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, 721008, Shaanxi, China. chenkailiyajie@163.com.Present Address: Guangzhou Institute of Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No. 78 Hengzhigang, Guangzhou, 510095, Guangdong, China. huang_zhenpeng@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33627079

Citation

Zhang, Hua, et al. "Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) in Patients Out of Wuhan From China: a Case Control Study." BMC Infectious Diseases, vol. 21, no. 1, 2021, p. 207.
Zhang H, Du F, Cao XJ, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study. BMC Infect Dis. 2021;21(1):207.
Zhang, H., Du, F., Cao, X. J., Feng, X. L., Zhang, H. P., Wu, Z. X., Wang, B. F., Zhang, H. J., Liu, R., Yang, J. J., Ning, B., Chen, K., & Huang, Z. P. (2021). Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study. BMC Infectious Diseases, 21(1), 207. https://doi.org/10.1186/s12879-021-05897-z
Zhang H, et al. Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) in Patients Out of Wuhan From China: a Case Control Study. BMC Infect Dis. 2021 Feb 24;21(1):207. PubMed PMID: 33627079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study. AU - Zhang,Hua, AU - Du,Feng, AU - Cao,Xiao-Jun, AU - Feng,Xia-Long, AU - Zhang,He-Ping, AU - Wu,Zheng-Xia, AU - Wang,Bao-Feng, AU - Zhang,Hong-Juan, AU - Liu,Rui, AU - Yang,Jian-Jun, AU - Ning,Bo, AU - Chen,Kai, AU - Huang,Zhen-Peng, Y1 - 2021/02/24/ PY - 2020/02/20/received PY - 2021/02/12/accepted PY - 2021/2/25/entrez PY - 2021/2/26/pubmed PY - 2021/3/2/medline KW - 2019-nCoV KW - COVID-19 KW - China KW - Clinical characteristics KW - Wuhan SP - 207 EP - 207 JF - BMC infectious diseases JO - BMC Infect Dis VL - 21 IS - 1 N2 - BACKGROUND: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China. METHODS: Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe). RESULTS: Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05). CONCLUSION: Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/33627079/Clinical_characteristics_of_coronavirus_disease_2019__COVID_19__in_patients_out_of_Wuhan_from_China:_a_case_control_study_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-05897-z DB - PRIME DP - Unbound Medicine ER -