Tags

Type your tag names separated by a space and hit enter

Paraganglioma of the cauda equina: an ultrastructural and immunohistochemical study of two cases.
Ultrastruct Pathol. 1988 Mar-Apr; 12(2):235-43.UP

Abstract

The ultrastructural and immunohistochemical features of 2 paragangliomas arising in the cauda equina are described. In both cases the tumor cells were arranged in small nests or cords and contained characteristic neurosecretory granules, lamellar stacks of rough endoplasmic reticulum (RER), and some well-developed Golgi apparatuses in their cytoplasm. The cells varied in electron density; the darker cells, occasionally resembling sustentacular cells, were probably dehydrated light cells because they contained a few neurosecretory granules. Sustentacular cells were difficult to identify by electron microscopy, but irregularly distributed S-100 protein and glial fibrillary acidic protein (GFAP) were found in these cells by immunostaining. Many tumor cells contained abundant neurofilaments. Curiously, a few cytokeratin-positive cells were found in 1 case. On microscopic examination, a small area of ganglioneuroma was found associated with the paraganglioma in 1 case. Ganglionic differentiation was concluded to be frequent in paragangliomas of the cauda equina region as in duodenal paragangliomas.

Authors+Show Affiliations

First Department of Pathology, University of Tokushima School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3363684

Citation

Hirose, T, et al. "Paraganglioma of the Cauda Equina: an Ultrastructural and Immunohistochemical Study of Two Cases." Ultrastructural Pathology, vol. 12, no. 2, 1988, pp. 235-43.
Hirose T, Sano T, Mori K, et al. Paraganglioma of the cauda equina: an ultrastructural and immunohistochemical study of two cases. Ultrastruct Pathol. 1988;12(2):235-43.
Hirose, T., Sano, T., Mori, K., Kagawa, N., Sakaki, A., Kuwamura, Y., & Hizawa, K. (1988). Paraganglioma of the cauda equina: an ultrastructural and immunohistochemical study of two cases. Ultrastructural Pathology, 12(2), 235-43.
Hirose T, et al. Paraganglioma of the Cauda Equina: an Ultrastructural and Immunohistochemical Study of Two Cases. Ultrastruct Pathol. 1988 Mar-Apr;12(2):235-43. PubMed PMID: 3363684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraganglioma of the cauda equina: an ultrastructural and immunohistochemical study of two cases. AU - Hirose,T, AU - Sano,T, AU - Mori,K, AU - Kagawa,N, AU - Sakaki,A, AU - Kuwamura,Y, AU - Hizawa,K, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 235 EP - 43 JF - Ultrastructural pathology JO - Ultrastruct Pathol VL - 12 IS - 2 N2 - The ultrastructural and immunohistochemical features of 2 paragangliomas arising in the cauda equina are described. In both cases the tumor cells were arranged in small nests or cords and contained characteristic neurosecretory granules, lamellar stacks of rough endoplasmic reticulum (RER), and some well-developed Golgi apparatuses in their cytoplasm. The cells varied in electron density; the darker cells, occasionally resembling sustentacular cells, were probably dehydrated light cells because they contained a few neurosecretory granules. Sustentacular cells were difficult to identify by electron microscopy, but irregularly distributed S-100 protein and glial fibrillary acidic protein (GFAP) were found in these cells by immunostaining. Many tumor cells contained abundant neurofilaments. Curiously, a few cytokeratin-positive cells were found in 1 case. On microscopic examination, a small area of ganglioneuroma was found associated with the paraganglioma in 1 case. Ganglionic differentiation was concluded to be frequent in paragangliomas of the cauda equina region as in duodenal paragangliomas. SN - 0191-3123 UR - https://www.unboundmedicine.com/medline/citation/3363684/Paraganglioma_of_the_cauda_equina:_an_ultrastructural_and_immunohistochemical_study_of_two_cases_ L2 - https://www.tandfonline.com/doi/full/10.3109/01913128809058221 DB - PRIME DP - Unbound Medicine ER -