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Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43.
J Perinatol. 2021 05; 41(5):952-960.JP

Abstract

OBJECTIVE

The influence of previous viral symptoms on the level and duration of human milk antibodies reactive to SARS-CoV-2, and common human coronaviruses (HCoVs) was investigated.

STUDY DESIGN

Antibodies reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E were measured via ELISA in human milk samples collected from March to June 2020 in mothers with and without viral symptoms.

RESULTS

The presence of viral symptoms influenced the levels of SARS-CoV-2 S2-reactive SIgA/IgA and tended to influence SARS-CoV-2 S1 SIgA/IgA and S2-reactive SIgM/IgM in human milk but did not relate to IgG. HCoV-229E S1 + S2-reactive SIgA/IgA and SIgM/IgM, as well as HCoV-OC43 S1 + S2-reactive IgG were related to the symptoms. The duration of antibody levels in human milk in mothers with viral symptoms varied between 3 and 4 months post maternal report of viral symptoms.

CONCLUSION

Previous viral symptoms and individual mothers may change the antibody cross-reactive levels to SARS-CoV-2 and HCoVs in human milk.

Authors+Show Affiliations

Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA. vdemers-m@medolac.com.Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.Department of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33649442

Citation

Demers-Mathieu, Veronique, et al. "Previous Viral Symptoms and Individual Mothers Influenced the Leveled Duration of Human Milk Antibodies Cross-reactive to S1 and S2 Subunits From SARS-CoV-2, HCoV-229E, and HCoV-OC43." Journal of Perinatology : Official Journal of the California Perinatal Association, vol. 41, no. 5, 2021, pp. 952-960.
Demers-Mathieu V, DaPra C, Mathijssen GB, et al. Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43. J Perinatol. 2021;41(5):952-960.
Demers-Mathieu, V., DaPra, C., Mathijssen, G. B., & Medo, E. (2021). Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43. Journal of Perinatology : Official Journal of the California Perinatal Association, 41(5), 952-960. https://doi.org/10.1038/s41372-021-01001-0
Demers-Mathieu V, et al. Previous Viral Symptoms and Individual Mothers Influenced the Leveled Duration of Human Milk Antibodies Cross-reactive to S1 and S2 Subunits From SARS-CoV-2, HCoV-229E, and HCoV-OC43. J Perinatol. 2021;41(5):952-960. PubMed PMID: 33649442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43. AU - Demers-Mathieu,Veronique, AU - DaPra,Ciera, AU - Mathijssen,Gabrielle B, AU - Medo,Elena, Y1 - 2021/03/01/ PY - 2020/11/04/received PY - 2021/02/05/accepted PY - 2021/01/29/revised PY - 2021/3/3/pubmed PY - 2021/5/27/medline PY - 2021/3/2/entrez SP - 952 EP - 960 JF - Journal of perinatology : official journal of the California Perinatal Association JO - J Perinatol VL - 41 IS - 5 N2 - OBJECTIVE: The influence of previous viral symptoms on the level and duration of human milk antibodies reactive to SARS-CoV-2, and common human coronaviruses (HCoVs) was investigated. STUDY DESIGN: Antibodies reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E were measured via ELISA in human milk samples collected from March to June 2020 in mothers with and without viral symptoms. RESULTS: The presence of viral symptoms influenced the levels of SARS-CoV-2 S2-reactive SIgA/IgA and tended to influence SARS-CoV-2 S1 SIgA/IgA and S2-reactive SIgM/IgM in human milk but did not relate to IgG. HCoV-229E S1 + S2-reactive SIgA/IgA and SIgM/IgM, as well as HCoV-OC43 S1 + S2-reactive IgG were related to the symptoms. The duration of antibody levels in human milk in mothers with viral symptoms varied between 3 and 4 months post maternal report of viral symptoms. CONCLUSION: Previous viral symptoms and individual mothers may change the antibody cross-reactive levels to SARS-CoV-2 and HCoVs in human milk. SN - 1476-5543 UR - https://www.unboundmedicine.com/medline/citation/33649442/Previous_viral_symptoms_and_individual_mothers_influenced_the_leveled_duration_of_human_milk_antibodies_cross_reactive_to_S1_and_S2_subunits_from_SARS_CoV_2_HCoV_229E_and_HCoV_OC43_ L2 - https://doi.org/10.1038/s41372-021-01001-0 DB - PRIME DP - Unbound Medicine ER -