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Emerging high-level ciprofloxacin-resistant Salmonella enterica serovar typhi haplotype H58 in travelers returning to the Republic of Korea from India.
PLoS Negl Trop Dis. 2021 03; 15(3):e0009170.PN

Abstract

In Korea, typhoid fever is a rare disease due to improved living standards. However, typhoid fever remains a major burden in developing countries and regions, such as India and Southeast Asia. In this study, we isolated Salmonella Typhi (S. Typhi) from eight patients with typhoid fever who were travelers returning from India. The strains isolated were characterized by antimicrobial susceptibility profiling and whole-genome sequencing (WGS) analysis. All strains were resistant to nalidixic acid and azithromycin. Among them, four isolates were highly resistant to ciprofloxacin (MIC ≥32 μg/ml); these strains have not been confirmed in Korea PulseNet DB. According to WGS, the ciprofloxacin-resistant strains belong to the global dominant multidrug-resistant (MDR) haplotype H58 (SNP glpA C1047T, SptP protein Q185* (premature stop codon)) and do not harbor the MDR plasmid. H58-associated SNPs in membrane and metabolism genes, including yhdA, yajI, hyaE, tryE, rlpB and metH, are present. Additionally, phylogenetic analysis assigned the H58 strains to sublineage II, whereas the non-H58 strains are closely related to haplotype H50. The presence of high-level ciprofloxacin-resistant S. Typhi haplotype H58 in Korea was first confirmed as due to influx from overseas via travelers. This study provides information about intercontinental drug-resistant transmission between countries and suggests that travelers need to be careful about personal hygiene.

Authors+Show Affiliations

Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea. College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.Division of Infectious Diseases Control, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.Division of Infectious Diseases Control, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.Division of Bacterial Diseases, Korea Centers for Diseases Control and Prevention, Cheongju, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33651791

Citation

Shin, Eunkyung, et al. "Emerging High-level Ciprofloxacin-resistant Salmonella Enterica Serovar Typhi Haplotype H58 in Travelers Returning to the Republic of Korea From India." PLoS Neglected Tropical Diseases, vol. 15, no. 3, 2021, pp. e0009170.
Shin E, Park J, Jeong HJ, et al. Emerging high-level ciprofloxacin-resistant Salmonella enterica serovar typhi haplotype H58 in travelers returning to the Republic of Korea from India. PLoS Negl Trop Dis. 2021;15(3):e0009170.
Shin, E., Park, J., Jeong, H. J., Park, A. K., Na, K., Lee, H., Chun, J. H., Hwang, K. J., Kim, C. J., & Kim, J. (2021). Emerging high-level ciprofloxacin-resistant Salmonella enterica serovar typhi haplotype H58 in travelers returning to the Republic of Korea from India. PLoS Neglected Tropical Diseases, 15(3), e0009170. https://doi.org/10.1371/journal.pntd.0009170
Shin E, et al. Emerging High-level Ciprofloxacin-resistant Salmonella Enterica Serovar Typhi Haplotype H58 in Travelers Returning to the Republic of Korea From India. PLoS Negl Trop Dis. 2021;15(3):e0009170. PubMed PMID: 33651791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging high-level ciprofloxacin-resistant Salmonella enterica serovar typhi haplotype H58 in travelers returning to the Republic of Korea from India. AU - Shin,Eunkyung, AU - Park,Jungsun, AU - Jeong,Hyun Ju, AU - Park,Ae Kyung, AU - Na,Kyoungin, AU - Lee,Hyerim, AU - Chun,Jeong-Hoon, AU - Hwang,Kyu Jam, AU - Kim,Chul-Joong, AU - Kim,Junyoung, Y1 - 2021/03/02/ PY - 2020/04/27/received PY - 2021/01/22/accepted PY - 2021/03/23/revised PY - 2021/3/3/pubmed PY - 2021/6/29/medline PY - 2021/3/2/entrez SP - e0009170 EP - e0009170 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 15 IS - 3 N2 - In Korea, typhoid fever is a rare disease due to improved living standards. However, typhoid fever remains a major burden in developing countries and regions, such as India and Southeast Asia. In this study, we isolated Salmonella Typhi (S. Typhi) from eight patients with typhoid fever who were travelers returning from India. The strains isolated were characterized by antimicrobial susceptibility profiling and whole-genome sequencing (WGS) analysis. All strains were resistant to nalidixic acid and azithromycin. Among them, four isolates were highly resistant to ciprofloxacin (MIC ≥32 μg/ml); these strains have not been confirmed in Korea PulseNet DB. According to WGS, the ciprofloxacin-resistant strains belong to the global dominant multidrug-resistant (MDR) haplotype H58 (SNP glpA C1047T, SptP protein Q185* (premature stop codon)) and do not harbor the MDR plasmid. H58-associated SNPs in membrane and metabolism genes, including yhdA, yajI, hyaE, tryE, rlpB and metH, are present. Additionally, phylogenetic analysis assigned the H58 strains to sublineage II, whereas the non-H58 strains are closely related to haplotype H50. The presence of high-level ciprofloxacin-resistant S. Typhi haplotype H58 in Korea was first confirmed as due to influx from overseas via travelers. This study provides information about intercontinental drug-resistant transmission between countries and suggests that travelers need to be careful about personal hygiene. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/33651791/Emerging_high_level_ciprofloxacin_resistant_Salmonella_enterica_serovar_typhi_haplotype_H58_in_travelers_returning_to_the_Republic_of_Korea_from_India_ L2 - https://dx.plos.org/10.1371/journal.pntd.0009170 DB - PRIME DP - Unbound Medicine ER -