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Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 5th communication: effects on immunological reactions in mice and humans.
Arzneimittelforschung. 1988 Jan; 38(1):88-92.A

Abstract

The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on immunological reactions in mice and humans were studied in view of possible side effects. Hemagglutinin formation in mice immunized with sheep red blood cells was not suppressed by WP-833 administered i.p. or p.o. for 3 days either before or after immunization. In addition, the same treatments with WP-833 showed no suppression of hapten-specific immunoglobulin E (IgE) or immunoglobulin G (IgG) antibody formation in mice immunized with dinitrophenyl-conjugated ovalbumin mixed with alum. The proliferation of human peripheral blood lymphocytes induced by concanavalin A, phytohemagglutinin-P, pokeweed mitogen, protein A or Cowan I was not suppressed by WP-833. Nitroblue tetrazolium reduction test, phagocytosis and chemotaxis in human neutrophils were not inhibited by WP-833.

Authors+Show Affiliations

Clinical Research Center for Allergy, National Sagamihara Hospital, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3365280

Citation

Yanagihara, Y, et al. "Immunopharmacological Actions of the New Antiallergic Drug Butyl 3'-(1H-tetrazol-5-yl)oxanilate. 5th Communication: Effects On Immunological Reactions in Mice and Humans." Arzneimittel-Forschung, vol. 38, no. 1, 1988, pp. 88-92.
Yanagihara Y, Abe T, Kuroda T, et al. Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 5th communication: effects on immunological reactions in mice and humans. Arzneimittelforschung. 1988;38(1):88-92.
Yanagihara, Y., Abe, T., Kuroda, T., & Shida, T. (1988). Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 5th communication: effects on immunological reactions in mice and humans. Arzneimittel-Forschung, 38(1), 88-92.
Yanagihara Y, et al. Immunopharmacological Actions of the New Antiallergic Drug Butyl 3'-(1H-tetrazol-5-yl)oxanilate. 5th Communication: Effects On Immunological Reactions in Mice and Humans. Arzneimittelforschung. 1988;38(1):88-92. PubMed PMID: 3365280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunopharmacological actions of the new antiallergic drug butyl 3'-(1H-tetrazol-5-yl)oxanilate. 5th communication: effects on immunological reactions in mice and humans. AU - Yanagihara,Y, AU - Abe,T, AU - Kuroda,T, AU - Shida,T, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 88 EP - 92 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 38 IS - 1 N2 - The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic drug, on immunological reactions in mice and humans were studied in view of possible side effects. Hemagglutinin formation in mice immunized with sheep red blood cells was not suppressed by WP-833 administered i.p. or p.o. for 3 days either before or after immunization. In addition, the same treatments with WP-833 showed no suppression of hapten-specific immunoglobulin E (IgE) or immunoglobulin G (IgG) antibody formation in mice immunized with dinitrophenyl-conjugated ovalbumin mixed with alum. The proliferation of human peripheral blood lymphocytes induced by concanavalin A, phytohemagglutinin-P, pokeweed mitogen, protein A or Cowan I was not suppressed by WP-833. Nitroblue tetrazolium reduction test, phagocytosis and chemotaxis in human neutrophils were not inhibited by WP-833. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3365280/Immunopharmacological_actions_of_the_new_antiallergic_drug_butyl_3'__1H_tetrazol_5_yl_oxanilate__5th_communication:_effects_on_immunological_reactions_in_mice_and_humans_ DB - PRIME DP - Unbound Medicine ER -