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Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses.
bioRxiv. 2021 Feb 23B

Abstract

Globally there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21). Using Syrian hamsters that model moderate to severe COVID-19 disease, we demonstrate the high efficacy of PiN-21 to prevent and treat SARS-CoV-2 infection. Intranasal delivery of PiN-21 at 0.6 mg/kg protects infected animals from weight loss and substantially reduces viral burdens in both lower and upper airways compared to control. Aerosol delivery of PiN-21 facilitates deposition throughout the respiratory tract and dose minimization to 0.2 mg/kg. Inhalation treatment quickly reverses animals' weight loss post-infection and decreases lung viral titers by 6 logs leading to drastically mitigated lung pathology and prevents viral pneumonia. Combined with the marked stability and low production cost, this novel therapy may provide a convenient and cost-effective option to mitigate the ongoing pandemic.

Authors

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Pub Type(s)

Preprint

Language

eng

PubMed ID

33655253

Citation

Nambulli, Sham, et al. "Inhalable Nanobody (PiN-21) Prevents and Treats SARS-CoV-2 Infections in Syrian Hamsters at Ultra-low Doses." BioRxiv : the Preprint Server for Biology, 2021.
Nambulli S, Xiang Y, Tilston-Lunel NL, et al. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. bioRxiv. 2021.
Nambulli, S., Xiang, Y., Tilston-Lunel, N. L., Rennick, L. J., Sang, Z., Klimstra, W. B., Reed, D. S., Crossland, N. A., Shi, Y., & Duprex, W. P. (2021). Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. BioRxiv : the Preprint Server for Biology. https://doi.org/10.1101/2021.02.23.432569
Nambulli S, et al. Inhalable Nanobody (PiN-21) Prevents and Treats SARS-CoV-2 Infections in Syrian Hamsters at Ultra-low Doses. bioRxiv. 2021 Feb 23; PubMed PMID: 33655253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. AU - Nambulli,Sham, AU - Xiang,Yufei, AU - Tilston-Lunel,Natasha L, AU - Rennick,Linda J, AU - Sang,Zhe, AU - Klimstra,William B, AU - Reed,Douglas S, AU - Crossland,Nicholas A, AU - Shi,Yi, AU - Duprex,W Paul, Y1 - 2021/02/23/ PY - 2021/3/3/entrez PY - 2021/3/4/pubmed PY - 2021/3/4/medline JF - bioRxiv : the preprint server for biology JO - bioRxiv N2 - Globally there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21). Using Syrian hamsters that model moderate to severe COVID-19 disease, we demonstrate the high efficacy of PiN-21 to prevent and treat SARS-CoV-2 infection. Intranasal delivery of PiN-21 at 0.6 mg/kg protects infected animals from weight loss and substantially reduces viral burdens in both lower and upper airways compared to control. Aerosol delivery of PiN-21 facilitates deposition throughout the respiratory tract and dose minimization to 0.2 mg/kg. Inhalation treatment quickly reverses animals' weight loss post-infection and decreases lung viral titers by 6 logs leading to drastically mitigated lung pathology and prevents viral pneumonia. Combined with the marked stability and low production cost, this novel therapy may provide a convenient and cost-effective option to mitigate the ongoing pandemic. UR - https://www.unboundmedicine.com/medline/citation/33655253/Inhalable_Nanobody_(PiN-21)_prevents_and_treats_SARS-CoV-2_infections_in_Syrian_hamsters_at_ultra-low_doses. L2 - https://doi.org/10.1101/2021.02.23.432569 DB - PRIME DP - Unbound Medicine ER -
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