Tags

Type your tag names separated by a space and hit enter

Smoking and drinking in relation to oral and pharyngeal cancer.
Cancer Res. 1988 Jun 01; 48(11):3282-7.CR

Abstract

A case-control study of oral and pharyngeal cancer conducted in four areas of the United States provided information on the tobacco and alcohol use of 1114 patients and 1268 population-based controls. Because of the large study size, it could be shown that the risks of these cancers among nondrinkers increased with amount smoked, and conversely that the risks among nonsmokers increased with the level of alcohol intake. Among consumers of both products, risks of oropharyngeal cancer tended to combine more in a multiplicative than additive fashion and were increased more than 35-fold among those who consumed two or more packs of cigarettes and more than four alcoholic drinks/day. Cigarette, cigar, and pipe smoking were separately implicated, although it was shown for the first time that risk was not as high among male lifelong filter cigarette smokers. Cessation of smoking was associated with a sharply reduced risk of this cancer, with no excess detected among those having quit for 10 or more years, suggesting that smoking affects primarily a late stage in the process of oropharyngeal carcinogenesis. The risks varied by type of alcoholic beverage, being higher among those consuming hard liquor or beer than wine. The relative risk patterns were generally similar among whites and blacks, and among males and females, and showed little difference when oral and pharyngeal cancers were analyzed separately. From calculations of attributable risk, we estimate that tobacco smoking and alcohol drinking combine to account for approximately three-fourths of all oral and pharyngeal cancers in the United States.

Authors+Show Affiliations

National Cancer Institute, Bethesda, Maryland 20892.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3365707

Citation

Blot, W J., et al. "Smoking and Drinking in Relation to Oral and Pharyngeal Cancer." Cancer Research, vol. 48, no. 11, 1988, pp. 3282-7.
Blot WJ, McLaughlin JK, Winn DM, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48(11):3282-7.
Blot, W. J., McLaughlin, J. K., Winn, D. M., Austin, D. F., Greenberg, R. S., Preston-Martin, S., Bernstein, L., Schoenberg, J. B., Stemhagen, A., & Fraumeni, J. F. (1988). Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Research, 48(11), 3282-7.
Blot WJ, et al. Smoking and Drinking in Relation to Oral and Pharyngeal Cancer. Cancer Res. 1988 Jun 1;48(11):3282-7. PubMed PMID: 3365707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking and drinking in relation to oral and pharyngeal cancer. AU - Blot,W J, AU - McLaughlin,J K, AU - Winn,D M, AU - Austin,D F, AU - Greenberg,R S, AU - Preston-Martin,S, AU - Bernstein,L, AU - Schoenberg,J B, AU - Stemhagen,A, AU - Fraumeni,J F,Jr PY - 1988/6/1/pubmed PY - 2001/3/28/medline PY - 1988/6/1/entrez SP - 3282 EP - 7 JF - Cancer research JO - Cancer Res. VL - 48 IS - 11 N2 - A case-control study of oral and pharyngeal cancer conducted in four areas of the United States provided information on the tobacco and alcohol use of 1114 patients and 1268 population-based controls. Because of the large study size, it could be shown that the risks of these cancers among nondrinkers increased with amount smoked, and conversely that the risks among nonsmokers increased with the level of alcohol intake. Among consumers of both products, risks of oropharyngeal cancer tended to combine more in a multiplicative than additive fashion and were increased more than 35-fold among those who consumed two or more packs of cigarettes and more than four alcoholic drinks/day. Cigarette, cigar, and pipe smoking were separately implicated, although it was shown for the first time that risk was not as high among male lifelong filter cigarette smokers. Cessation of smoking was associated with a sharply reduced risk of this cancer, with no excess detected among those having quit for 10 or more years, suggesting that smoking affects primarily a late stage in the process of oropharyngeal carcinogenesis. The risks varied by type of alcoholic beverage, being higher among those consuming hard liquor or beer than wine. The relative risk patterns were generally similar among whites and blacks, and among males and females, and showed little difference when oral and pharyngeal cancers were analyzed separately. From calculations of attributable risk, we estimate that tobacco smoking and alcohol drinking combine to account for approximately three-fourths of all oral and pharyngeal cancers in the United States. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/3365707/Smoking_and_drinking_in_relation_to_oral_and_pharyngeal_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=3365707 DB - PRIME DP - Unbound Medicine ER -