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Salchaetoglobosins A and B: Cytochalasan alkaloids from Chaetomium globosum D38, a fungus derived from Salvia miltiorrhiza.
Fitoterapia. 2021 Jun; 151:104874.F

Abstract

Chemical investigation on the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, has afforded two new 19,20-seco-chaetoglobosins, salchaetoglobosins A (1) and B (2), along with three known analogues, chaetoglobosins E (3), Fex (4), and Vb (5). Their structures and absolute configurations were elucidated by a set of spectroscopy and single-crystal X-ray crystallography. Compounds 1-5 were evaluated for their cytotoxic activities against HCT-116 (colorectal carcinoma) and PC3 (prostate cancer) cells, as well as the NO production inhibitory effects in LPS-stimulated RAW264.7 cells.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ji J
Department of Chinese Medicine Authentication, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; School of Life sciences, Inner Mongolia University, 235 West University Road, Hohhot 010021, China.
Liu C
Department of Chinese Medicine Authentication, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
He X
Department of Chinese Medicine Authentication, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Chen G
School of Life sciences, Inner Mongolia University, 235 West University Road, Hohhot 010021, China.
Qin L
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: qinsmmu@126.com.
Zheng C
Department of Chinese Medicine Authentication, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: cjzheng1984@126.com.

MeSH

AnimalsAnti-Inflammatory AgentsAntineoplastic AgentsChaetomiumChinaDrug Screening Assays, AntitumorHCT116 CellsHumansIndole AlkaloidsMiceMolecular StructureNitric OxidePC-3 CellsRAW 264.7 CellsSalvia miltiorrhiza

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33667565

Citation

Ji, Jiacheng, et al. "Salchaetoglobosins a and B: Cytochalasan Alkaloids From Chaetomium Globosum D38, a Fungus Derived From Salvia Miltiorrhiza." Fitoterapia, vol. 151, 2021, p. 104874.
Ji J, Liu C, He X, et al. Salchaetoglobosins A and B: Cytochalasan alkaloids from Chaetomium globosum D38, a fungus derived from Salvia miltiorrhiza. Fitoterapia. 2021;151:104874.
Ji, J., Liu, C., He, X., Chen, G., Qin, L., & Zheng, C. (2021). Salchaetoglobosins A and B: Cytochalasan alkaloids from Chaetomium globosum D38, a fungus derived from Salvia miltiorrhiza. Fitoterapia, 151, 104874. https://doi.org/10.1016/j.fitote.2021.104874
Ji J, et al. Salchaetoglobosins a and B: Cytochalasan Alkaloids From Chaetomium Globosum D38, a Fungus Derived From Salvia Miltiorrhiza. Fitoterapia. 2021;151:104874. PubMed PMID: 33667565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salchaetoglobosins A and B: Cytochalasan alkaloids from Chaetomium globosum D38, a fungus derived from Salvia miltiorrhiza. AU - Ji,Jiacheng, AU - Liu,Chang, AU - He,Xuhui, AU - Chen,Guilin, AU - Qin,Luping, AU - Zheng,Chengjian, Y1 - 2021/03/03/ PY - 2021/02/10/received PY - 2021/02/25/revised PY - 2021/02/28/accepted PY - 2021/3/6/pubmed PY - 2021/9/18/medline PY - 2021/3/5/entrez KW - Chaetoglobosins KW - Chaetomium globosum D38 KW - Cytotoxic activities KW - NO production inhibitory effects KW - Salvia miltiorrhiza SP - 104874 EP - 104874 JF - Fitoterapia JO - Fitoterapia VL - 151 N2 - Chemical investigation on the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, has afforded two new 19,20-seco-chaetoglobosins, salchaetoglobosins A (1) and B (2), along with three known analogues, chaetoglobosins E (3), Fex (4), and Vb (5). Their structures and absolute configurations were elucidated by a set of spectroscopy and single-crystal X-ray crystallography. Compounds 1-5 were evaluated for their cytotoxic activities against HCT-116 (colorectal carcinoma) and PC3 (prostate cancer) cells, as well as the NO production inhibitory effects in LPS-stimulated RAW264.7 cells. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/33667565/Salchaetoglobosins_A_and_B:_Cytochalasan_alkaloids_from_Chaetomium_globosum_D38_a_fungus_derived_from_Salvia_miltiorrhiza_ DB - PRIME DP - Unbound Medicine ER -