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Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review.
Molecules. 2021 Feb 19; 26(4)M

Abstract

Despite the improvements in life expectancy, neurodegenerative conditions have arguably become the most dreaded maladies of older people. The neuroprotective and anti-ageing potentials of essential oils (EOs) are widely evaluated around the globe. The objective of this review is to analyse the effectiveness of EOs as neuroprotective remedies among the four common age-related neurodegenerative diseases. The literature was extracted from three databases (PubMed, Web of Science and Google Scholar) between the years of 2010 to 2020 using the medical subject heading (MeSH) terms "essential oil", crossed with "Alzheimer's disease (AD)", "Huntington's disease (HD)", "Parkinson's disease (PD)" or "amyotrophic lateral sclerosis (ALS)". Eighty three percent (83%) of the studies were focused on AD, while another 12% focused on PD. No classifiable study was recorded on HD or ALS. EO from Salvia officinalis has been recorded as one of the most effective acetylcholinesterase and butyrylcholinesterase inhibitors. However, only Cinnamomum sp. has been assessed for its effectiveness in both AD and PD. Our review provided useful evidence on EOs as potential neuroprotective remedies for age-related neurodegenerative diseases.

Authors+Show Affiliations

Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, No.1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, No.1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, No.1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33669787

Citation

Abd Rashed, Aswir, et al. "Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: a Review." Molecules (Basel, Switzerland), vol. 26, no. 4, 2021.
Abd Rashed A, Abd Rahman AZ, Rathi DNG. Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review. Molecules. 2021;26(4).
Abd Rashed, A., Abd Rahman, A. Z., & Rathi, D. N. G. (2021). Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review. Molecules (Basel, Switzerland), 26(4). https://doi.org/10.3390/molecules26041107
Abd Rashed A, Abd Rahman AZ, Rathi DNG. Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: a Review. Molecules. 2021 Feb 19;26(4) PubMed PMID: 33669787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review. AU - Abd Rashed,Aswir, AU - Abd Rahman,Ahmad Zuhairi, AU - Rathi,Devi Nair Gunasegavan, Y1 - 2021/02/19/ PY - 2020/12/30/received PY - 2021/01/22/revised PY - 2021/01/25/accepted PY - 2021/3/6/entrez PY - 2021/3/7/pubmed PY - 2021/3/7/medline KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - amyotrophic lateral sclerosis KW - essential oils KW - in vitro KW - in vivo KW - neurodegenerative JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 4 N2 - Despite the improvements in life expectancy, neurodegenerative conditions have arguably become the most dreaded maladies of older people. The neuroprotective and anti-ageing potentials of essential oils (EOs) are widely evaluated around the globe. The objective of this review is to analyse the effectiveness of EOs as neuroprotective remedies among the four common age-related neurodegenerative diseases. The literature was extracted from three databases (PubMed, Web of Science and Google Scholar) between the years of 2010 to 2020 using the medical subject heading (MeSH) terms "essential oil", crossed with "Alzheimer's disease (AD)", "Huntington's disease (HD)", "Parkinson's disease (PD)" or "amyotrophic lateral sclerosis (ALS)". Eighty three percent (83%) of the studies were focused on AD, while another 12% focused on PD. No classifiable study was recorded on HD or ALS. EO from Salvia officinalis has been recorded as one of the most effective acetylcholinesterase and butyrylcholinesterase inhibitors. However, only Cinnamomum sp. has been assessed for its effectiveness in both AD and PD. Our review provided useful evidence on EOs as potential neuroprotective remedies for age-related neurodegenerative diseases. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/33669787/Essential_Oils_as_a_Potential_Neuroprotective_Remedy_for_Age_Related_Neurodegenerative_Diseases:_A_Review_ L2 - https://www.mdpi.com/resolver?pii=molecules26041107 DB - PRIME DP - Unbound Medicine ER -