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Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles.
Carbohydr Polym. 2021 May 01; 259:117640.CP

Abstract

In this study, the electrospun poly(ε-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber was fabricated successfully with curcumin loaded chitosan nano-encapsulated particles (CURCSNPs). The morphology of the produced CURCSNPs, PCL, PCL/CS, PCL/CS/CUR, and PCL/CS/CUR electrosprayed with CURCSNPs were analyzed by scanning electron microscopy (SEM). The physicochemical properties and biological characteristics of fabricated nanofibers such as antibacterial, antioxidant, cell viability, and in vivo wound healing efficiency and histological assay were tested. The electrospraying of CURCSNPs on surface PCL/CS/CUR nanofiber resulted in the enhanced antibacterial, antioxidant, cell proliferation efficiencies and higher swelling and water vapor transition rates. In vivo examination and Histological analysis showed PCL/CS/CUR electrosprayed with CURCSNPs led to significant improvement of complete well-organized wound healing process in MRSA infected wounds. These results suggest that the application of PCL/CS/CUR electrosprayed with CURCSNPs as a wound dressing significantly facilitates wound healing with notable antibacterial, antioxidant, and cell proliferation properties.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Fahimirad S
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
Abtahi H
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran. Electronic address: abtahi@arakmu.ac.ir.
Satei P
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
Ghaznavi-Rad E
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran; Department of Medical Laboratory Sciences, Arak School of Paramedicine, Arak University of Medical Sciences, Arak, Iran.
Moslehi M
School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Ganji A
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran; Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

MeSH

AnimalsAnti-Bacterial AgentsAntioxidantsBiocompatible MaterialsCell LineCell ProliferationCell SurvivalChitosanCurcuminEscherichia coliHumansMaleMethicillin-Resistant Staphylococcus aureusMiceNanofibersNanoparticlesPolyestersTensile StrengthWound Healing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33673981

Citation

Fahimirad, Shohreh, et al. "Wound Healing Performance of PCL/chitosan Based Electrospun Nanofiber Electrosprayed With Curcumin Loaded Chitosan Nanoparticles." Carbohydrate Polymers, vol. 259, 2021, p. 117640.
Fahimirad S, Abtahi H, Satei P, et al. Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles. Carbohydr Polym. 2021;259:117640.
Fahimirad, S., Abtahi, H., Satei, P., Ghaznavi-Rad, E., Moslehi, M., & Ganji, A. (2021). Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles. Carbohydrate Polymers, 259, 117640. https://doi.org/10.1016/j.carbpol.2021.117640
Fahimirad S, et al. Wound Healing Performance of PCL/chitosan Based Electrospun Nanofiber Electrosprayed With Curcumin Loaded Chitosan Nanoparticles. Carbohydr Polym. 2021 May 1;259:117640. PubMed PMID: 33673981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles. AU - Fahimirad,Shohreh, AU - Abtahi,Hamid, AU - Satei,Parastu, AU - Ghaznavi-Rad,Ehsanollah, AU - Moslehi,Mohsen, AU - Ganji,Ali, Y1 - 2021/01/25/ PY - 2020/10/12/received PY - 2020/11/27/revised PY - 2021/01/09/accepted PY - 2021/3/7/pubmed PY - 2021/4/15/medline PY - 2021/3/6/entrez KW - Chitosan KW - Curcumin KW - Curcumin loaded chitosan nano-encapsulated particles (CURCSNPs) KW - Electrospraying KW - Electrospun nanofiber KW - Poly(ε-caprolactone) SP - 117640 EP - 117640 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 259 N2 - In this study, the electrospun poly(ε-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber was fabricated successfully with curcumin loaded chitosan nano-encapsulated particles (CURCSNPs). The morphology of the produced CURCSNPs, PCL, PCL/CS, PCL/CS/CUR, and PCL/CS/CUR electrosprayed with CURCSNPs were analyzed by scanning electron microscopy (SEM). The physicochemical properties and biological characteristics of fabricated nanofibers such as antibacterial, antioxidant, cell viability, and in vivo wound healing efficiency and histological assay were tested. The electrospraying of CURCSNPs on surface PCL/CS/CUR nanofiber resulted in the enhanced antibacterial, antioxidant, cell proliferation efficiencies and higher swelling and water vapor transition rates. In vivo examination and Histological analysis showed PCL/CS/CUR electrosprayed with CURCSNPs led to significant improvement of complete well-organized wound healing process in MRSA infected wounds. These results suggest that the application of PCL/CS/CUR electrosprayed with CURCSNPs as a wound dressing significantly facilitates wound healing with notable antibacterial, antioxidant, and cell proliferation properties. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/33673981/Wound_healing_performance_of_PCL/chitosan_based_electrospun_nanofiber_electrosprayed_with_curcumin_loaded_chitosan_nanoparticles_ DB - PRIME DP - Unbound Medicine ER -
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