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Synthesis of gold nanoparticles/polyaniline boronic acid/sodium alginate aqueous nanocomposite based on chemical oxidative polymerization for biological applications.
Int J Biol Macromol. 2021 May 15; 179:196-205.IJ

Abstract

Gold nanoparticles/polyaniline boronic acid/sodium alginate aqueous nanocomposite ((PABA-SAL)@AuNPs) was fabricated. Aniline boronic acid (ABA) served as reductant of gold salt, all within the SAL solution. While ABA reduced gold salt to its nanoparticles, the ABA monomer was also oxidized to its conducting polymeric form (PABA). The presence of PABA in the reaction mixture exerted solubility and stability challenge, thus SAL was used as stabilizer and solubilizer for PABA. The numerous cis-diol groups of SAL could bind to boronic acid groups of PABA to furnish PABA-SAL repeating polymer structure for AuNPs anchoring. Sparkling ruby red (PABA-SAL)@AuNPs have absorption peaks at 529 and 718 nm. Average particle sizes of nanocomposite were within 15-20 nm, with hydrodynamic diameter of 48.6 ± 0.9 nm, zeta potential of -32.5 ± 1.6 mV and conductivity value of 2015.3 ± 3.2 μS/cm. (PABA-SAL)@AuNPs possessed antibacterial activities against seafood associated bacterial isolates, with MIC and MBC ranging from 4 to 8 μg/mL. The moderate antioxidant capacity of (PABA-SAL)@AuNPs was observed, without any deleterious damages on human red blood cells. It also has good biocompatibility on Caco-2 and RAW 264.7, with cell viability not less than 70%. These results confirm the high prospect of (PABA-SAL)@AuNPs for possible biomedical applications.

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Authors+Show Affiliations

Jayeoye TJ
Center of Excellence for Innovation in Chemistry, Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Analytical Chemistry and Environment Research Unit, Faculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand; Department of Chemistry/Biochemistry/Molecular Biology, Alex-Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Ebonyi State, Nigeria.
Eze FN
Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Drug Delivery System Excellence Center, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Singh S
Excellence Research Laboratory on Natural Products, Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Olatunde OO
International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Benjakul S
International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Rujiralai T
Center of Excellence for Innovation in Chemistry, Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Analytical Chemistry and Environment Research Unit, Faculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand. Electronic address: thitima.r@psu.ac.th.

MeSH

AlginatesAniline CompoundsAnti-Bacterial AgentsBacteriaBoronic AcidsGoldMetal NanoparticlesNanocompositesOxidation-Reduction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33675826

Citation

Jayeoye, Titilope John, et al. "Synthesis of Gold Nanoparticles/polyaniline Boronic Acid/sodium Alginate Aqueous Nanocomposite Based On Chemical Oxidative Polymerization for Biological Applications." International Journal of Biological Macromolecules, vol. 179, 2021, pp. 196-205.
Jayeoye TJ, Eze FN, Singh S, et al. Synthesis of gold nanoparticles/polyaniline boronic acid/sodium alginate aqueous nanocomposite based on chemical oxidative polymerization for biological applications. Int J Biol Macromol. 2021;179:196-205.
Jayeoye, T. J., Eze, F. N., Singh, S., Olatunde, O. O., Benjakul, S., & Rujiralai, T. (2021). Synthesis of gold nanoparticles/polyaniline boronic acid/sodium alginate aqueous nanocomposite based on chemical oxidative polymerization for biological applications. International Journal of Biological Macromolecules, 179, 196-205. https://doi.org/10.1016/j.ijbiomac.2021.02.199
Jayeoye TJ, et al. Synthesis of Gold Nanoparticles/polyaniline Boronic Acid/sodium Alginate Aqueous Nanocomposite Based On Chemical Oxidative Polymerization for Biological Applications. Int J Biol Macromol. 2021 May 15;179:196-205. PubMed PMID: 33675826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of gold nanoparticles/polyaniline boronic acid/sodium alginate aqueous nanocomposite based on chemical oxidative polymerization for biological applications. AU - Jayeoye,Titilope John, AU - Eze,Fredrick Nwude, AU - Singh,Sudarshan, AU - Olatunde,Oladipupo Odunayo, AU - Benjakul,Soottawat, AU - Rujiralai,Thitima, Y1 - 2021/03/03/ PY - 2020/12/09/received PY - 2021/02/25/revised PY - 2021/02/26/accepted PY - 2021/3/7/pubmed PY - 2021/7/23/medline PY - 2021/3/6/entrez KW - Aniline boronic acid KW - Biocompatibility KW - Gold nanoparticles KW - Nanocomposite KW - Sodium alginate SP - 196 EP - 205 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 179 N2 - Gold nanoparticles/polyaniline boronic acid/sodium alginate aqueous nanocomposite ((PABA-SAL)@AuNPs) was fabricated. Aniline boronic acid (ABA) served as reductant of gold salt, all within the SAL solution. While ABA reduced gold salt to its nanoparticles, the ABA monomer was also oxidized to its conducting polymeric form (PABA). The presence of PABA in the reaction mixture exerted solubility and stability challenge, thus SAL was used as stabilizer and solubilizer for PABA. The numerous cis-diol groups of SAL could bind to boronic acid groups of PABA to furnish PABA-SAL repeating polymer structure for AuNPs anchoring. Sparkling ruby red (PABA-SAL)@AuNPs have absorption peaks at 529 and 718 nm. Average particle sizes of nanocomposite were within 15-20 nm, with hydrodynamic diameter of 48.6 ± 0.9 nm, zeta potential of -32.5 ± 1.6 mV and conductivity value of 2015.3 ± 3.2 μS/cm. (PABA-SAL)@AuNPs possessed antibacterial activities against seafood associated bacterial isolates, with MIC and MBC ranging from 4 to 8 μg/mL. The moderate antioxidant capacity of (PABA-SAL)@AuNPs was observed, without any deleterious damages on human red blood cells. It also has good biocompatibility on Caco-2 and RAW 264.7, with cell viability not less than 70%. These results confirm the high prospect of (PABA-SAL)@AuNPs for possible biomedical applications. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/33675826/Synthesis_of_gold_nanoparticles/polyaniline_boronic_acid/sodium_alginate_aqueous_nanocomposite_based_on_chemical_oxidative_polymerization_for_biological_applications_ DB - PRIME DP - Unbound Medicine ER -