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Human limbal epithelial stem cell regulation, bioengineering and function.
Prog Retin Eye Res. 2021 Mar 04 [Online ahead of print]PR

Abstract

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a cell population harbored in a highly regulated niche located at the limbus. Dysfunction and/or loss of LSCs and their niche cause limbal stem cell deficiency (LSCD), a disease that is marked by invasion of conjunctival epithelium into the cornea and results in failure of epithelial wound healing. Corneal opacity, pain, loss of vision, and blindness are the consequences of LSCD. Successful treatment of LSCD depends on accurate diagnosis and staging of the disease and requires restoration of functional LSCs and their niche. This review highlights the major advances in the identification of potential LSC biomarkers and components of the LSC niche, understanding of LSC regulation, methods and regulatory standards in bioengineering of LSCs, and diagnosis and staging of LSCD. Overall, this review presents key points for researchers and clinicians alike to consider in deepening the understanding of LSC biology and improving LSCD therapies.

Authors+Show Affiliations

Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA; Cornea Department, Paris University, Cochin Hospital, AP-HP, F-75014, Paris, France.Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.Basic Science Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA.Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA. Electronic address: deng@jsei.ucla.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33676006

Citation

Bonnet, Clémence, et al. "Human Limbal Epithelial Stem Cell Regulation, Bioengineering and Function." Progress in Retinal and Eye Research, 2021, p. 100956.
Bonnet C, González S, Roberts JS, et al. Human limbal epithelial stem cell regulation, bioengineering and function. Prog Retin Eye Res. 2021.
Bonnet, C., González, S., Roberts, J. S., Robertson, S. Y. T., Ruiz, M., Zheng, J., & Deng, S. X. (2021). Human limbal epithelial stem cell regulation, bioengineering and function. Progress in Retinal and Eye Research, 100956. https://doi.org/10.1016/j.preteyeres.2021.100956
Bonnet C, et al. Human Limbal Epithelial Stem Cell Regulation, Bioengineering and Function. Prog Retin Eye Res. 2021 Mar 4;100956. PubMed PMID: 33676006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human limbal epithelial stem cell regulation, bioengineering and function. AU - Bonnet,Clémence, AU - González,Sheyla, AU - Roberts,JoAnn S, AU - Robertson,Sarah Y T, AU - Ruiz,Maxime, AU - Zheng,Jie, AU - Deng,Sophie X, Y1 - 2021/03/04/ PY - 2020/10/01/received PY - 2021/02/21/revised PY - 2021/02/26/accepted PY - 2022/09/04/pmc-release PY - 2021/3/7/pubmed PY - 2021/3/7/medline PY - 2021/3/6/entrez KW - Anterior segment coherence tomography KW - Cell therapy KW - In vivo laser scanning confocal microscopy KW - Limbal stem cell KW - Limbal stem cell deficiency KW - Notch signaling pathway KW - Small molecules KW - Wnt signaling pathway SP - 100956 EP - 100956 JF - Progress in retinal and eye research JO - Prog Retin Eye Res N2 - The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a cell population harbored in a highly regulated niche located at the limbus. Dysfunction and/or loss of LSCs and their niche cause limbal stem cell deficiency (LSCD), a disease that is marked by invasion of conjunctival epithelium into the cornea and results in failure of epithelial wound healing. Corneal opacity, pain, loss of vision, and blindness are the consequences of LSCD. Successful treatment of LSCD depends on accurate diagnosis and staging of the disease and requires restoration of functional LSCs and their niche. This review highlights the major advances in the identification of potential LSC biomarkers and components of the LSC niche, understanding of LSC regulation, methods and regulatory standards in bioengineering of LSCs, and diagnosis and staging of LSCD. Overall, this review presents key points for researchers and clinicians alike to consider in deepening the understanding of LSC biology and improving LSCD therapies. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/33676006/Human_limbal_epithelial_stem_cell_regulation,_bioengineering_and_function. L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(21)00017-3 DB - PRIME DP - Unbound Medicine ER -
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