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Raman spectroscopic analysis of skin penetration and moisturizing effects of Bionics vernix caseosa cream compared with Vaseline.
Technol Health Care. 2021; 29(S1):327-334.TH

Abstract

BACKGROUND

The stratum corneum (SC) is the outermost layer of human skin and deemed as barrier against chemical exposure and water loss. Moisturizers have beneficial effects in treating dry skin, especially the SC. Confocal Raman spectroscopy (CRS) was used to evaluate the efficacy of moisturizers on skin hydration and penetration, with such agents posing inherent characteristics of being noninvasive, nondestructive, timesaving, and cost effective. Bionics vernix caseosa (BVC) cream mimics the composition of vernix caseosa (VC), which could protect the newborn skin.

METHODS

This research applied CRS to evaluate the penetration depth and water content variation during the intervention with two moisturizers, BVC cream and Vaseline. Volunteers received the 2 h application of BVC cream and Vaseline on the forearms. The evaluations on 0 h, 2 h, 4 h and 6 h were performed clinical assessment. Experimental data was processed by least square method and analysis of variance (ANOVA).

RESULTS

The penetration depth of Vaseline was deeper than that of Bionics vernix caseosa cream. Specifically, BVC cream penetrated 18 μm into human skin, while Vaseline penetrated at least 20 μm. Compared with Vaseline, only BVC cream increased skin hydration, with a moisturizing effect lasting for 4 h. At 6 h, the Vaseline moisturizing effect decreased significantly.

Links

Authors+Show Affiliations

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

Beijing Academy of TCM Beauty Supplements, Beijing 100048, China.

Nutri-Woods Bio-Tech (Beijing) Co., Ltd., Beijing 100048, China.

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

Beijing International Studies University, Beijing 100000, China.

Institute of Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.

MeSH

BionicsHumansInfant, NewbornPetrolatumSkinSpectrum Analysis, RamanVernix Caseosa

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33682769

Citation

Meng, Hong, et al. "Raman Spectroscopic Analysis of Skin Penetration and Moisturizing Effects of Bionics Vernix Caseosa Cream Compared With Vaseline." Technology and Health Care : Official Journal of the European Society for Engineering and Medicine, vol. 29, no. S1, 2021, pp. 327-334.

Meng H, Yin Y, Wu W, et al. Raman spectroscopic analysis of skin penetration and moisturizing effects of Bionics vernix caseosa cream compared with Vaseline. Technol Health Care. 2021;29(S1):327-334.

Meng, H., Yin, Y., Wu, W., Liu, Y., Li, L., Dong, Y., Fan, Y., Li, Y., & He, Y. (2021). Raman spectroscopic analysis of skin penetration and moisturizing effects of Bionics vernix caseosa cream compared with Vaseline. Technology and Health Care : Official Journal of the European Society for Engineering and Medicine, 29(S1), 327-334. https://doi.org/10.3233/THC-218030

Meng H, et al. Raman Spectroscopic Analysis of Skin Penetration and Moisturizing Effects of Bionics Vernix Caseosa Cream Compared With Vaseline. Technol Health Care. 2021;29(S1):327-334. PubMed PMID: 33682769.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Raman spectroscopic analysis of skin penetration and moisturizing effects of Bionics vernix caseosa cream compared with Vaseline. AU - Meng,Hong, AU - Yin,Yating, AU - Wu,Wenhai, AU - Liu,Yuhong, AU - Li,Li, AU - Dong,Yinmao, AU - Fan,Yi, AU - Li,Yue, AU - He,Yifan, PY - 2021/3/9/pubmed PY - 2021/9/18/medline PY - 2021/3/8/entrez KW - Bionics vernix caseosa cream KW - Vaseline KW - confocal Raman spectroscopy KW - hydration KW - penetration SP - 327 EP - 334 JF - Technology and health care : official journal of the European Society for Engineering and Medicine JO - Technol Health Care VL - 29 IS - S1 N2 - BACKGROUND: The stratum corneum (SC) is the outermost layer of human skin and deemed as barrier against chemical exposure and water loss. Moisturizers have beneficial effects in treating dry skin, especially the SC. Confocal Raman spectroscopy (CRS) was used to evaluate the efficacy of moisturizers on skin hydration and penetration, with such agents posing inherent characteristics of being noninvasive, nondestructive, timesaving, and cost effective. Bionics vernix caseosa (BVC) cream mimics the composition of vernix caseosa (VC), which could protect the newborn skin. METHODS: This research applied CRS to evaluate the penetration depth and water content variation during the intervention with two moisturizers, BVC cream and Vaseline. Volunteers received the 2 h application of BVC cream and Vaseline on the forearms. The evaluations on 0 h, 2 h, 4 h and 6 h were performed clinical assessment. Experimental data was processed by least square method and analysis of variance (ANOVA). RESULTS: The penetration depth of Vaseline was deeper than that of Bionics vernix caseosa cream. Specifically, BVC cream penetrated 18 μm into human skin, while Vaseline penetrated at least 20 μm. Compared with Vaseline, only BVC cream increased skin hydration, with a moisturizing effect lasting for 4 h. At 6 h, the Vaseline moisturizing effect decreased significantly. SN - 1878-7401 UR - https://www.unboundmedicine.com/medline/citation/33682769/Raman_spectroscopic_analysis_of_skin_penetration_and_moisturizing_effects_of_Bionics_vernix_caseosa_cream_compared_with_Vaseline_ DB - PRIME DP - Unbound Medicine ER -