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Frequency of asthma exacerbation in children during the coronavirus disease pandemic with strict mitigative countermeasures.
Pediatr Pulmonol. 2021 06; 56(6):1455-1463.PP

Abstract

BACKGROUND

Strict countermeasures for coronavirus disease (COVID-19) were undertaken in China without knowing their influence on asthma.

OBJECTIVE

To investigate the associations between the frequencies of asthma exacerbations and respiratory infections and air pollutants before and during the COVID-19 pandemic, which were direct consequences of countermeasures undertaken for the pandemic.

METHODS

Asthma exacerbations and respiratory infections among hospitalized children in the permanent population of Guangzhou City, China, from February to June 2016-2019 (before the pandemic) to February to June 2020 (during the pandemic) were collected in this cross-sectional study in Guangzhou.

RESULTS

The number of asthma exacerbation cases per month documented in the Guangzhou Women and Children's Hospital before (median: 13.5; range: 0-48) and during (median: 20; range: 0-34) the mitigative response to the COVID-19 pandemic was similar. The frequency of severe asthma exacerbation cases per month decreased, whereas that of mild asthma exacerbation cases per year increased (p = .004). The number of patients hospitalized with infectious respiratory diseases decreased from 146 (range: 90-172) per month before the pandemic to 42 (range: 33-57) per month during the pandemic (p = .004). Most pathogens and air pollutants decreased during the COVID-19 pandemic. The frequency of severe asthma exacerbations positively correlated to that of respiratory infections in children, but did not correlate to air pollutants.

CONCLUSION

Strict countermeasures undertaken for the pandemic were associated with a decreased the frequency of infectious respiratory diseases and severe asthma exacerbations among urban children.

Authors+Show Affiliations

Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.Department of Transplantation, The Second Affiliated Hospital of Southern University of Science and Technology and the Third People's Hospital of Shenzhen, Shenzhen, China.Department of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33684257

Citation

Fan, Hui-Feng, et al. "Frequency of Asthma Exacerbation in Children During the Coronavirus Disease Pandemic With Strict Mitigative Countermeasures." Pediatric Pulmonology, vol. 56, no. 6, 2021, pp. 1455-1463.
Fan HF, He CH, Yin GQ, et al. Frequency of asthma exacerbation in children during the coronavirus disease pandemic with strict mitigative countermeasures. Pediatr Pulmonol. 2021;56(6):1455-1463.
Fan, H. F., He, C. H., Yin, G. Q., Qin, Y., Jiang, N., Lu, G., & Li, X. (2021). Frequency of asthma exacerbation in children during the coronavirus disease pandemic with strict mitigative countermeasures. Pediatric Pulmonology, 56(6), 1455-1463. https://doi.org/10.1002/ppul.25335
Fan HF, et al. Frequency of Asthma Exacerbation in Children During the Coronavirus Disease Pandemic With Strict Mitigative Countermeasures. Pediatr Pulmonol. 2021;56(6):1455-1463. PubMed PMID: 33684257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of asthma exacerbation in children during the coronavirus disease pandemic with strict mitigative countermeasures. AU - Fan,Hui-Feng, AU - He,Chun-Hui, AU - Yin,Gen-Quan, AU - Qin,Yi, AU - Jiang,Nan, AU - Lu,Gen, AU - Li,Xing, Y1 - 2021/03/08/ PY - 2021/02/17/revised PY - 2020/12/22/received PY - 2021/02/21/accepted PY - 2021/3/9/pubmed PY - 2021/6/2/medline PY - 2021/3/8/entrez KW - COVID-19 KW - air pollution KW - asthma exacerbation KW - prevention KW - respiratory infection SP - 1455 EP - 1463 JF - Pediatric pulmonology JO - Pediatr Pulmonol VL - 56 IS - 6 N2 - BACKGROUND: Strict countermeasures for coronavirus disease (COVID-19) were undertaken in China without knowing their influence on asthma. OBJECTIVE: To investigate the associations between the frequencies of asthma exacerbations and respiratory infections and air pollutants before and during the COVID-19 pandemic, which were direct consequences of countermeasures undertaken for the pandemic. METHODS: Asthma exacerbations and respiratory infections among hospitalized children in the permanent population of Guangzhou City, China, from February to June 2016-2019 (before the pandemic) to February to June 2020 (during the pandemic) were collected in this cross-sectional study in Guangzhou. RESULTS: The number of asthma exacerbation cases per month documented in the Guangzhou Women and Children's Hospital before (median: 13.5; range: 0-48) and during (median: 20; range: 0-34) the mitigative response to the COVID-19 pandemic was similar. The frequency of severe asthma exacerbation cases per month decreased, whereas that of mild asthma exacerbation cases per year increased (p = .004). The number of patients hospitalized with infectious respiratory diseases decreased from 146 (range: 90-172) per month before the pandemic to 42 (range: 33-57) per month during the pandemic (p = .004). Most pathogens and air pollutants decreased during the COVID-19 pandemic. The frequency of severe asthma exacerbations positively correlated to that of respiratory infections in children, but did not correlate to air pollutants. CONCLUSION: Strict countermeasures undertaken for the pandemic were associated with a decreased the frequency of infectious respiratory diseases and severe asthma exacerbations among urban children. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/33684257/Frequency_of_asthma_exacerbation_in_children_during_the_coronavirus_disease_pandemic_with_strict_mitigative_countermeasures_ L2 - https://doi.org/10.1002/ppul.25335 DB - PRIME DP - Unbound Medicine ER -