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Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway.
Biosci Biotechnol Biochem. 2021 Mar 24; 85(4):775-785.BB

Abstract

This research aimed to evaluate the antihepatic fibrosis effect and explore the mechanism of Qiwei Qinggan Powder (QGS-7) in vivo and in vitro. Carbon tetrachloride (CCl4)-treated rats and hepatic stellate cells (HSCs) were used. QGS-7 treatment significantly improved the liver function of rats as indicated by decreased serum enzymatic activities of alanine aminotransferase, aspartate transaminase, and alkaline phosphatase. Meanwhile, the hydroxyproline of liver was significantly decreased. Histopathological results indicated that QGS-7 alleviated liver damage and reduced the formation of fibrosis septa. Moreover, QGS-7 significantly attenuated expressions of Alpha smooth muscle actin, Collagen I, Janus kinase 2 (JAK2), phosphorylation-JAK2, signal transducer and activator of transcription 3 (STAT3), phosphorylation-STAT3 in the rat hepatic fibrosis model. QGS-7 inhibited HSC proliferation and promoted it apoptosis. QGS-7 may affect hepatic fibrosis through JAK2/STAT3 signaling pathway so as to play an antihepatic fibrosis role.

Authors+Show Affiliations

Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Pathology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Physiology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Pharmaceutical Engineering, School of Pharmacy, Inner Mongolia Medical University, Hohhot, China.Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Biochemistry, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Department of Biochemistry, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.School of Mongolian Medicine and Pharmacy, Inner Mongolia Medical University, Hohhot, China.Functional Science laboratory, Institute of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.Key Laboratory of Molecular Pathology Inner, Inner Mongolia Medical University, Hohhot City, Inner Mongolia Autonomous Region, China.Department of Pharmacology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33686395

Citation

Liang, Jie, et al. "Study On the Effect of Mongolian Medicine Qiwei Qinggan Powder On Hepatic Fibrosis Through JAK2/STAT3 Pathway." Bioscience, Biotechnology, and Biochemistry, vol. 85, no. 4, 2021, pp. 775-785.
Liang J, Yuan H, Xu L, et al. Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway. Biosci Biotechnol Biochem. 2021;85(4):775-785.
Liang, J., Yuan, H., Xu, L., Wang, F., Bao, X., Yan, Y., Wang, H., Zhang, C., Jin, R., Ma, L., Zhang, J., Huri, L., Su, X., Xiao, R., & Ma, Y. (2021). Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway. Bioscience, Biotechnology, and Biochemistry, 85(4), 775-785. https://doi.org/10.1093/bbb/zbab001
Liang J, et al. Study On the Effect of Mongolian Medicine Qiwei Qinggan Powder On Hepatic Fibrosis Through JAK2/STAT3 Pathway. Biosci Biotechnol Biochem. 2021 Mar 24;85(4):775-785. PubMed PMID: 33686395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway. AU - Liang,Jie, AU - Yuan,Hongwei, AU - Xu,Liping, AU - Wang,Feng, AU - Bao,Xiaomei, AU - Yan,Yuxin, AU - Wang,Haisheng, AU - Zhang,Chunyan, AU - Jin,Rong, AU - Ma,Lijie, AU - Zhang,Jianyu, AU - Huri,Lebagen, AU - Su,Xiaoli, AU - Xiao,Rui, AU - Ma,Yuehong, PY - 2020/12/07/accepted PY - 2020/08/27/received PY - 2021/3/10/pubmed PY - 2021/7/27/medline PY - 2021/3/9/entrez KW - HSC-T6 cells KW - JAK2/STAT3 pathway KW - Qiwei Qinggan Powder (QGS-7) KW - hepatic fibrosis SP - 775 EP - 785 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 85 IS - 4 N2 - This research aimed to evaluate the antihepatic fibrosis effect and explore the mechanism of Qiwei Qinggan Powder (QGS-7) in vivo and in vitro. Carbon tetrachloride (CCl4)-treated rats and hepatic stellate cells (HSCs) were used. QGS-7 treatment significantly improved the liver function of rats as indicated by decreased serum enzymatic activities of alanine aminotransferase, aspartate transaminase, and alkaline phosphatase. Meanwhile, the hydroxyproline of liver was significantly decreased. Histopathological results indicated that QGS-7 alleviated liver damage and reduced the formation of fibrosis septa. Moreover, QGS-7 significantly attenuated expressions of Alpha smooth muscle actin, Collagen I, Janus kinase 2 (JAK2), phosphorylation-JAK2, signal transducer and activator of transcription 3 (STAT3), phosphorylation-STAT3 in the rat hepatic fibrosis model. QGS-7 inhibited HSC proliferation and promoted it apoptosis. QGS-7 may affect hepatic fibrosis through JAK2/STAT3 signaling pathway so as to play an antihepatic fibrosis role. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/33686395/Study_on_the_effect_of_Mongolian_medicine_Qiwei_Qinggan_Powder_on_hepatic_fibrosis_through_JAK2/STAT3_pathway_ L2 - https://academic.oup.com/bbb/article-lookup/doi/10.1093/bbb/zbab001 DB - PRIME DP - Unbound Medicine ER -