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What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology.
J Mol Cell Biol. 2021 07 06; 13(3):175-184.JM

Abstract

Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

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Authors+Show Affiliations

Altulea D
Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
Maassen S
Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
Baranov MV
Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
van den Bogaart G
Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands. Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

MeSH

Antiviral AgentsCOVID-19Cell ProliferationChloroquineDrug RepositioningHumansHydroxychloroquineSARS-CoV-2COVID-19 Drug Treatment

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33693723

Citation

Altulea, Dania, et al. "What Makes (hydroxy)chloroquine Ineffective Against COVID-19: Insights From Cell Biology." Journal of Molecular Cell Biology, vol. 13, no. 3, 2021, pp. 175-184.
Altulea D, Maassen S, Baranov MV, et al. What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology. J Mol Cell Biol. 2021;13(3):175-184.
Altulea, D., Maassen, S., Baranov, M. V., & van den Bogaart, G. (2021). What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology. Journal of Molecular Cell Biology, 13(3), 175-184. https://doi.org/10.1093/jmcb/mjab016
Altulea D, et al. What Makes (hydroxy)chloroquine Ineffective Against COVID-19: Insights From Cell Biology. J Mol Cell Biol. 2021 07 6;13(3):175-184. PubMed PMID: 33693723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology. AU - Altulea,Dania, AU - Maassen,Sjors, AU - Baranov,Maksim V, AU - van den Bogaart,G, PY - 2020/10/05/received PY - 2021/02/17/revised PY - 2021/02/24/accepted PY - 2021/3/12/pubmed PY - 2021/7/16/medline PY - 2021/3/11/entrez KW - COVID-19 KW - SARS-CoV-2 KW - chloroquine KW - coronavirus KW - hydroxychloroquine SP - 175 EP - 184 JF - Journal of molecular cell biology JO - J Mol Cell Biol VL - 13 IS - 3 N2 - Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections. SN - 1759-4685 UR - https://www.unboundmedicine.com/medline/citation/33693723/What_makes__hydroxy_chloroquine_ineffective_against_COVID_19:_insights_from_cell_biology_ DB - PRIME DP - Unbound Medicine ER -