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Cytoskeletal pathology in ataxia-telangiectasia.
Clin Neuropathol. 1988 Jan-Feb; 7(1):44-6.CN

Abstract

Neuropathological features of a case of ataxia-telangiectasia are reported. The main findings were the presence of Lewy bodies, cytoplasmic inclusions and axonal spheroids in the brainstem nuclei; pathological changes of spinal cord closely resembled those reported in the familial form of amyotrophic lateral sclerosis. In immunocytochemical studies, filamentous inclusions and axonal spheroids strongly reacted with monoclonal antibodies against neurofilament subunits. The results show that disorganization and accumulation of neurofilament proteins occur in ataxia-telangiectasia.

Authors+Show Affiliations

Neuropathology Unit, Institute of Neurology, University of Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3370863

Citation

Monaco, S, et al. "Cytoskeletal Pathology in Ataxia-telangiectasia." Clinical Neuropathology, vol. 7, no. 1, 1988, pp. 44-6.
Monaco S, Nardelli E, Moretto G, et al. Cytoskeletal pathology in ataxia-telangiectasia. Clin Neuropathol. 1988;7(1):44-6.
Monaco, S., Nardelli, E., Moretto, G., Cavallaro, T., & Rizzuto, N. (1988). Cytoskeletal pathology in ataxia-telangiectasia. Clinical Neuropathology, 7(1), 44-6.
Monaco S, et al. Cytoskeletal Pathology in Ataxia-telangiectasia. Clin Neuropathol. 1988 Jan-Feb;7(1):44-6. PubMed PMID: 3370863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytoskeletal pathology in ataxia-telangiectasia. AU - Monaco,S, AU - Nardelli,E, AU - Moretto,G, AU - Cavallaro,T, AU - Rizzuto,N, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 44 EP - 6 JF - Clinical neuropathology JO - Clin. Neuropathol. VL - 7 IS - 1 N2 - Neuropathological features of a case of ataxia-telangiectasia are reported. The main findings were the presence of Lewy bodies, cytoplasmic inclusions and axonal spheroids in the brainstem nuclei; pathological changes of spinal cord closely resembled those reported in the familial form of amyotrophic lateral sclerosis. In immunocytochemical studies, filamentous inclusions and axonal spheroids strongly reacted with monoclonal antibodies against neurofilament subunits. The results show that disorganization and accumulation of neurofilament proteins occur in ataxia-telangiectasia. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/3370863/Cytoskeletal_pathology_in_ataxia_telangiectasia_ L2 - http://www.diseaseinfosearch.org/result/637 DB - PRIME DP - Unbound Medicine ER -