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2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses.
Clin Sci (Lond). 1988 May; 74(5):527-30.CS

Abstract

1. The effect of anaemia and transfusion with adult blood on fetal 2,3-diphosphoglycerate levels was investigated by studying fetal blood from 45 normal pregnancies at 17-42 weeks of gestation and in 34 pregnancies complicated by erythroblastosis fetalis. 2. In normal fetuses, 2,3-diphosphoglycerate concentration was higher than in adults and did not change significantly with gestational age. 3. In erythroblastotic fetuses, there was a significant negative correlation between 2,3-diphosphoglycerate concentration and haemoglobin concentration. 4. When adult blood was transfused into the fetal circulation, 2,3-diphosphoglycerate concentration reached similar levels to that found in untransfused fetuses after allowing for the severity of anaemia.

Authors+Show Affiliations

Soothill PW
Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London.
Lestas AN
No affiliation info available
Nicolaides KH
No affiliation info available
Rodeck CH
No affiliation info available
Bellingham AJ
No affiliation info available

MeSH

2,3-DiphosphoglycerateAdultBlood Transfusion, IntrauterineDiphosphoglyceric AcidsErythroblastosis, FetalErythrocyte CountFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornMalePregnancyReticulocytes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3370919

Citation

Soothill, P W., et al. "2,3-Diphosphoglycerate in Normal, Anaemic and Transfused Human Fetuses." Clinical Science (London, England : 1979), vol. 74, no. 5, 1988, pp. 527-30.
Soothill PW, Lestas AN, Nicolaides KH, et al. 2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses. Clin Sci (Lond). 1988;74(5):527-30.
Soothill, P. W., Lestas, A. N., Nicolaides, K. H., Rodeck, C. H., & Bellingham, A. J. (1988). 2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses. Clinical Science (London, England : 1979), 74(5), 527-30.
Soothill PW, et al. 2,3-Diphosphoglycerate in Normal, Anaemic and Transfused Human Fetuses. Clin Sci (Lond). 1988;74(5):527-30. PubMed PMID: 3370919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses. AU - Soothill,P W, AU - Lestas,A N, AU - Nicolaides,K H, AU - Rodeck,C H, AU - Bellingham,A J, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 527 EP - 30 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 74 IS - 5 N2 - 1. The effect of anaemia and transfusion with adult blood on fetal 2,3-diphosphoglycerate levels was investigated by studying fetal blood from 45 normal pregnancies at 17-42 weeks of gestation and in 34 pregnancies complicated by erythroblastosis fetalis. 2. In normal fetuses, 2,3-diphosphoglycerate concentration was higher than in adults and did not change significantly with gestational age. 3. In erythroblastotic fetuses, there was a significant negative correlation between 2,3-diphosphoglycerate concentration and haemoglobin concentration. 4. When adult blood was transfused into the fetal circulation, 2,3-diphosphoglycerate concentration reached similar levels to that found in untransfused fetuses after allowing for the severity of anaemia. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/3370919/23_Diphosphoglycerate_in_normal_anaemic_and_transfused_human_fetuses_ DB - PRIME DP - Unbound Medicine ER -