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Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula.
Prog Retin Eye Res. 2021 Sep; 84:100955.PR

Abstract

A wide range of ocular diseases can present with serous subretinal fluid in the macula and therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we categorise the diseases and conditions that are part of the differential diagnosis into 12 main pathogenic subgroups: neovascular diseases, vitelliform lesions, inflammatory diseases, ocular tumours, haematological malignancies, paraneoplastic syndromes, genetic diseases, ocular developmental anomalies, medication-related conditions and toxicity-related diseases, rhegmatogenous retinal detachment and tractional retinal detachment, retinal vascular diseases, and miscellaneous diseases. In addition, we describe 2 new clinical pictures associated with macular subretinal fluid accumulation, namely serous maculopathy with absence of retinal pigment epithelium (SMARPE) and serous maculopathy due to aspecific choroidopathy (SMACH). Differentiating between these various diseases and CSC can be challenging, and obtaining the correct diagnosis can have immediate therapeutic and prognostic consequences. Here, we describe the key differential diagnostic features of each disease within this clinical spectrum, including representative case examples. Moreover, we discuss the pathogenesis of each disease in order to facilitate the differentiation from typical CSC.

Authors+Show Affiliations

Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands; Department of Ophthalmology, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address: camiel.boon@amsterdamumc.nl.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33716160

Citation

van Dijk, Elon H C., and Camiel J F. Boon. "Serous Business: Delineating the Broad Spectrum of Diseases With Subretinal Fluid in the Macula." Progress in Retinal and Eye Research, vol. 84, 2021, p. 100955.
van Dijk EHC, Boon CJF. Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula. Prog Retin Eye Res. 2021;84:100955.
van Dijk, E. H. C., & Boon, C. J. F. (2021). Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula. Progress in Retinal and Eye Research, 84, 100955. https://doi.org/10.1016/j.preteyeres.2021.100955
van Dijk EHC, Boon CJF. Serous Business: Delineating the Broad Spectrum of Diseases With Subretinal Fluid in the Macula. Prog Retin Eye Res. 2021;84:100955. PubMed PMID: 33716160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serous business: Delineating the broad spectrum of diseases with subretinal fluid in the macula. AU - van Dijk,Elon H C, AU - Boon,Camiel J F, Y1 - 2021/03/11/ PY - 2020/11/30/received PY - 2021/02/14/revised PY - 2021/02/19/accepted PY - 2021/3/16/pubmed PY - 2021/3/16/medline PY - 2021/3/15/entrez KW - Central serous chorioretinopathy (CSC) KW - Differential diagnosis KW - Retinal disease KW - Serous fluid accumulation KW - Serous maculopathy SP - 100955 EP - 100955 JF - Progress in retinal and eye research JO - Prog Retin Eye Res VL - 84 N2 - A wide range of ocular diseases can present with serous subretinal fluid in the macula and therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we categorise the diseases and conditions that are part of the differential diagnosis into 12 main pathogenic subgroups: neovascular diseases, vitelliform lesions, inflammatory diseases, ocular tumours, haematological malignancies, paraneoplastic syndromes, genetic diseases, ocular developmental anomalies, medication-related conditions and toxicity-related diseases, rhegmatogenous retinal detachment and tractional retinal detachment, retinal vascular diseases, and miscellaneous diseases. In addition, we describe 2 new clinical pictures associated with macular subretinal fluid accumulation, namely serous maculopathy with absence of retinal pigment epithelium (SMARPE) and serous maculopathy due to aspecific choroidopathy (SMACH). Differentiating between these various diseases and CSC can be challenging, and obtaining the correct diagnosis can have immediate therapeutic and prognostic consequences. Here, we describe the key differential diagnostic features of each disease within this clinical spectrum, including representative case examples. Moreover, we discuss the pathogenesis of each disease in order to facilitate the differentiation from typical CSC. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/33716160/Serous_business:_Delineating_the_broad_spectrum_of_diseases_with_subretinal_fluid_in_the_macula. L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(21)00016-1 DB - PRIME DP - Unbound Medicine ER -
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