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Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19).
Indian J Clin Biochem. 2021 Mar 06 [Online ahead of print]IJ

Abstract

The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS) with a phenotype resembling Kawasaki disease (KD) ('Kawa-COVID-19'). Features of this newly recognized condition may include fever, hypotension, severe abdominal pain and cardiac dysfunction, evidence of inflammation, and single or multi organ dysfunction in the absence of other known infections. Children emerge to have mild symptoms compared to adults, perhaps due to reduced expression of the angiotensin converting enzyme (ACE)-2 receptor (the target of SARS-CoV-2) gene, trained innate immunity, and a young and fit immune system. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative although most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated.

Authors+Show Affiliations

Department of Paediatrics, College of Medicine and JNM Hospital, WBUHS Kalyani, Nadia, 741235 West Bengal India.Department of Biochemistry, College of Medicine and JNM Hospital, WBUHS Kalyani, Nadia, 741235 West Bengal India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33716413

Citation

Basu, Manjari, and Subir Kumar Das. "Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19)." Indian Journal of Clinical Biochemistry : IJCB, 2021, pp. 1-12.
Basu M, Das SK. Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19). Indian J Clin Biochem. 2021.
Basu, M., & Das, S. K. (2021). Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19). Indian Journal of Clinical Biochemistry : IJCB, 1-12. https://doi.org/10.1007/s12291-021-00963-4
Basu M, Das SK. Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19). Indian J Clin Biochem. 2021 Mar 6;1-12. PubMed PMID: 33716413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19). AU - Basu,Manjari, AU - Das,Subir Kumar, Y1 - 2021/03/06/ PY - 2020/08/15/received PY - 2021/02/17/accepted PY - 2021/3/15/entrez PY - 2021/3/16/pubmed PY - 2021/3/16/medline KW - Angiotensin converting enzyme KW - COVID-19 KW - Hyperinflammatory syndrome KW - Kawasaki Disease KW - Pediatric inflammatory multisystem syndrome KW - SARS-CoV-2 SP - 1 EP - 12 JF - Indian journal of clinical biochemistry : IJCB JO - Indian J Clin Biochem N2 - The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS) with a phenotype resembling Kawasaki disease (KD) ('Kawa-COVID-19'). Features of this newly recognized condition may include fever, hypotension, severe abdominal pain and cardiac dysfunction, evidence of inflammation, and single or multi organ dysfunction in the absence of other known infections. Children emerge to have mild symptoms compared to adults, perhaps due to reduced expression of the angiotensin converting enzyme (ACE)-2 receptor (the target of SARS-CoV-2) gene, trained innate immunity, and a young and fit immune system. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative although most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated. SN - 0970-1915 UR - https://www.unboundmedicine.com/medline/citation/33716413/Clinical_Characteristics_of_Paediatric_Hyperinflammatory_Syndrome_in_the_Era_of_Corona_Virus_Disease_2019__COVID_19__ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33716413/ DB - PRIME DP - Unbound Medicine ER -
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