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Identification and disruption of a neural mechanism for accumulating prospective metacognitive information prior to decision-making.
Neuron. 2021 04 21; 109(8):1396-1408.e7.N

Abstract

More than one type of probability must be considered when making decisions. It is as necessary to know one's chance of performing choices correctly as it is to know the chances that desired outcomes will follow choices. We refer to these two choice contingencies as internal and external probability. Neural activity across many frontal and parietal areas reflected internal and external probabilities in a similar manner during decision-making. However, neural recording and manipulation approaches suggest that one area, the anterior lateral prefrontal cortex (alPFC), is highly specialized for making prospective, metacognitive judgments on the basis of internal probability; it is essential for knowing which decisions to tackle, given its assessment of how well they will be performed. Its activity predicted prospective metacognitive judgments, and individual variation in activity predicted individual variation in metacognitive judgments. Its disruption altered metacognitive judgments, leading participants to tackle perceptual decisions they were likely to fail.

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Authors+Show Affiliations

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. Electronic address: kentaro.miyamoto@psy.ox.ac.uk.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Wellcome Centre for Integrative Neuroimaging (WIN), FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

MeSH

AdultBrain MappingFemaleHumansJudgmentMagnetic Resonance ImagingMaleMetacognitionNeuropsychological TestsPrefrontal CortexProspective StudiesTranscranial Magnetic Stimulation

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33730554

Citation

Miyamoto, Kentaro, et al. "Identification and Disruption of a Neural Mechanism for Accumulating Prospective Metacognitive Information Prior to Decision-making." Neuron, vol. 109, no. 8, 2021, pp. 1396-1408.e7.

Miyamoto K, Trudel N, Kamermans K, et al. Identification and disruption of a neural mechanism for accumulating prospective metacognitive information prior to decision-making. Neuron. 2021;109(8):1396-1408.e7.

Miyamoto, K., Trudel, N., Kamermans, K., Lim, M. C., Lazari, A., Verhagen, L., Wittmann, M. K., & Rushworth, M. F. S. (2021). Identification and disruption of a neural mechanism for accumulating prospective metacognitive information prior to decision-making. Neuron, 109(8), 1396-e7. https://doi.org/10.1016/j.neuron.2021.02.024

Miyamoto K, et al. Identification and Disruption of a Neural Mechanism for Accumulating Prospective Metacognitive Information Prior to Decision-making. Neuron. 2021 04 21;109(8):1396-1408.e7. PubMed PMID: 33730554.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Identification and disruption of a neural mechanism for accumulating prospective metacognitive information prior to decision-making. AU - Miyamoto,Kentaro, AU - Trudel,Nadescha, AU - Kamermans,Kevin, AU - Lim,Michele C, AU - Lazari,Alberto, AU - Verhagen,Lennart, AU - Wittmann,Marco K, AU - Rushworth,Matthew F S, Y1 - 2021/03/16/ PY - 2020/07/30/received PY - 2021/01/13/revised PY - 2021/02/19/accepted PY - 2021/3/18/pubmed PY - 2021/5/11/medline PY - 2021/3/17/entrez KW - anterior lateral prefrontal cortex KW - decision-making KW - functional magnetic resonance imaging KW - prospective metacognition KW - transcranial magnetic stimulation SP - 1396 EP - 1408.e7 JF - Neuron JO - Neuron VL - 109 IS - 8 N2 - More than one type of probability must be considered when making decisions. It is as necessary to know one's chance of performing choices correctly as it is to know the chances that desired outcomes will follow choices. We refer to these two choice contingencies as internal and external probability. Neural activity across many frontal and parietal areas reflected internal and external probabilities in a similar manner during decision-making. However, neural recording and manipulation approaches suggest that one area, the anterior lateral prefrontal cortex (alPFC), is highly specialized for making prospective, metacognitive judgments on the basis of internal probability; it is essential for knowing which decisions to tackle, given its assessment of how well they will be performed. Its activity predicted prospective metacognitive judgments, and individual variation in activity predicted individual variation in metacognitive judgments. Its disruption altered metacognitive judgments, leading participants to tackle perceptual decisions they were likely to fail. SN - 1097-4199 UR - https://www.unboundmedicine.com/medline/citation/33730554/Identification_and_disruption_of_a_neural_mechanism_for_accumulating_prospective_metacognitive_information_prior_to_decision_making_ DB - PRIME DP - Unbound Medicine ER -