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Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats.
Andrologia. 2021 Jul; 53(6):e14049.A

Abstract

Testicular torsion/detorsion is one of the important emergencies that requires fast surgical intervention. This study aimed to investigate the effects of Salvia miltiorrhiza hydroalcoholic extract combined with verapamil on testicular ischaemia/reperfusion damage in Wistar albino rats. All animals were distributed in 3 groups (n = 8), including the sham-operated group, torsion/detorsion (TD) group and torsion/detorsion + pretreatment with 200 mg/kg Salvia miltiorrhiza extract combined with 0.3 mg/kg verapamil (SMV) group. Oxidative stress biomarkers (MDA, GPx, CAT and TAC) both in plasma and testicular tissue, sperm parameters (motility, vitality, concentration and morphology) and histopathological parameters (MSTD, GECT, Johnson's score, Cosentino's score and testicular cell thickness) were assessed in all groups. Ischaemia/reperfusion significantly increased MDA and decreased GPx, CAT and TAC levels (p < .05). Pretreatment with SMV significantly increased GPx, CAT and TAC levels (p < .05). SMV group increased progressive sperm motility and vitality and reduced non-progressive motility of spermatozoon (p < .05). Testicular torsion significantly decreased all histopathological parameters compared to the sham group (p < .05). SMV pretreatment remarkably increased MSTD, GECT and Cosentino's score in comparison with the TD group (p < .05). A combination of Salvia miltiorrhiza with verapamil could reduce damages triggered by testicular torsion detorsion and improve sperm functionality parameters and oxidative stress defence systems.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Department of Clinical Sciences, Lorestan University, Khorramabad, Iran.Faculty of Veterinary Medicine, Department of Clinical Sciences, Lorestan University, Khorramabad, Iran. Faculty of Veterinary Medicine, Department of Surgery and Diagnostic Imaging, Urmia University, Urmia, Iran.Faculty of Veterinary Medicine, Department of Clinical Sciences, Lorestan University, Khorramabad, Iran.Faculty of Veterinary Medicine, Department of Clinical Sciences, Lorestan University, Khorramabad, Iran.Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Faculty of Medicine, Department of Anatomical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran.Razi Vaccine and Serum Research Institute, Agriculture Research, Education and Extension Organization (AREEO), Karaj, Iran.Department of Biotechnology, Inland Norway University of Applied Sciences, Hamar, Norway.Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Faculty of Medicine, Department of Biochemistry, Lorestan University of Medical Sciences, Khorramabad, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33733509

Citation

Taheri, Shayan, et al. "Co-administration of Salvia Miltiorrhiza and Verapamil Inhibits Detrimental Effects of Torsion/detorsion On Testicular Tissue in Rats." Andrologia, vol. 53, no. 6, 2021, pp. e14049.
Taheri S, Davoodi F, Raisi A, et al. Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats. Andrologia. 2021;53(6):e14049.
Taheri, S., Davoodi, F., Raisi, A., Zakian, A., Rajabzadeh, A., Hablolvarid, M. H., Khezri, A., & Ahmadvand, H. (2021). Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats. Andrologia, 53(6), e14049. https://doi.org/10.1111/and.14049
Taheri S, et al. Co-administration of Salvia Miltiorrhiza and Verapamil Inhibits Detrimental Effects of Torsion/detorsion On Testicular Tissue in Rats. Andrologia. 2021;53(6):e14049. PubMed PMID: 33733509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-administration of Salvia miltiorrhiza and verapamil inhibits detrimental effects of torsion/detorsion on testicular tissue in rats. AU - Taheri,Shayan, AU - Davoodi,Farshid, AU - Raisi,Abbas, AU - Zakian,Amir, AU - Rajabzadeh,Asghar, AU - Hablolvarid,Mohammad Hassan, AU - Khezri,Abdolrahman, AU - Ahmadvand,Hassan, Y1 - 2021/03/17/ PY - 2021/02/24/revised PY - 2021/01/14/received PY - 2021/02/27/accepted PY - 2021/3/19/pubmed PY - 2021/6/22/medline PY - 2021/3/18/entrez KW - oxidative stress KW - salvia miltiorrhiza KW - sperm parameters KW - testicular torsion KW - verapamil SP - e14049 EP - e14049 JF - Andrologia JO - Andrologia VL - 53 IS - 6 N2 - Testicular torsion/detorsion is one of the important emergencies that requires fast surgical intervention. This study aimed to investigate the effects of Salvia miltiorrhiza hydroalcoholic extract combined with verapamil on testicular ischaemia/reperfusion damage in Wistar albino rats. All animals were distributed in 3 groups (n = 8), including the sham-operated group, torsion/detorsion (TD) group and torsion/detorsion + pretreatment with 200 mg/kg Salvia miltiorrhiza extract combined with 0.3 mg/kg verapamil (SMV) group. Oxidative stress biomarkers (MDA, GPx, CAT and TAC) both in plasma and testicular tissue, sperm parameters (motility, vitality, concentration and morphology) and histopathological parameters (MSTD, GECT, Johnson's score, Cosentino's score and testicular cell thickness) were assessed in all groups. Ischaemia/reperfusion significantly increased MDA and decreased GPx, CAT and TAC levels (p < .05). Pretreatment with SMV significantly increased GPx, CAT and TAC levels (p < .05). SMV group increased progressive sperm motility and vitality and reduced non-progressive motility of spermatozoon (p < .05). Testicular torsion significantly decreased all histopathological parameters compared to the sham group (p < .05). SMV pretreatment remarkably increased MSTD, GECT and Cosentino's score in comparison with the TD group (p < .05). A combination of Salvia miltiorrhiza with verapamil could reduce damages triggered by testicular torsion detorsion and improve sperm functionality parameters and oxidative stress defence systems. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/33733509/Co_administration_of_Salvia_miltiorrhiza_and_verapamil_inhibits_detrimental_effects_of_torsion/detorsion_on_testicular_tissue_in_rats_ L2 - https://doi.org/10.1111/and.14049 DB - PRIME DP - Unbound Medicine ER -