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Novel approaches for vaccine development.
Cell. 2021 03 18; 184(6):1589-1603.Cell

Abstract

Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral pathogens, yet there are a number of examples where they have not been successful, such as for persistent infections, rapidly evolving pathogens with high sequence variability, complex viral antigens, and emerging pathogens. Novel technologies such as nucleic acid and viral vector vaccines offer the potential to revolutionize vaccine development as they are well-suited to address existing technology limitations. In this review, we discuss the current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges.

Authors+Show Affiliations

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.Moderna, Inc., Cambridge, MA, USA.Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.Moderna, Inc., Cambridge, MA, USA.Moderna, Inc., Cambridge, MA, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. Electronic address: andrea.carfi@modernatx.com.Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. Electronic address: dbarouch@bidmc.harvard.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33740454

Citation

Gebre, Makda S., et al. "Novel Approaches for Vaccine Development." Cell, vol. 184, no. 6, 2021, pp. 1589-1603.
Gebre MS, Brito LA, Tostanoski LH, et al. Novel approaches for vaccine development. Cell. 2021;184(6):1589-1603.
Gebre, M. S., Brito, L. A., Tostanoski, L. H., Edwards, D. K., Carfi, A., & Barouch, D. H. (2021). Novel approaches for vaccine development. Cell, 184(6), 1589-1603. https://doi.org/10.1016/j.cell.2021.02.030
Gebre MS, et al. Novel Approaches for Vaccine Development. Cell. 2021 03 18;184(6):1589-1603. PubMed PMID: 33740454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel approaches for vaccine development. AU - Gebre,Makda S, AU - Brito,Luis A, AU - Tostanoski,Lisa H, AU - Edwards,Darin K, AU - Carfi,Andrea, AU - Barouch,Dan H, PY - 2020/11/10/received PY - 2021/02/01/revised PY - 2021/02/12/accepted PY - 2022/03/18/pmc-release PY - 2021/3/19/entrez PY - 2021/3/20/pubmed PY - 2021/4/1/medline SP - 1589 EP - 1603 JF - Cell JO - Cell VL - 184 IS - 6 N2 - Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral pathogens, yet there are a number of examples where they have not been successful, such as for persistent infections, rapidly evolving pathogens with high sequence variability, complex viral antigens, and emerging pathogens. Novel technologies such as nucleic acid and viral vector vaccines offer the potential to revolutionize vaccine development as they are well-suited to address existing technology limitations. In this review, we discuss the current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges. SN - 1097-4172 UR - https://www.unboundmedicine.com/medline/citation/33740454/Novel_approaches_for_vaccine_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(21)00219-1 DB - PRIME DP - Unbound Medicine ER -