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Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential.
Biomed Pharmacother. 2021 Jun; 138:111511.BP

Abstract

Flavonoids are natural plant-derived dietary bioactive compounds having a substantial impact on human health. Morin hydrate is a bioflavonoid mainly obtained from fruits, stem, and leaves of Moraceae family members' plants. Plenty of evidences supported that morin hydrate exerts its beneficial effects against various chronic and life-threatening degenerative diseases. Our current article discloses the recent advances that have been studied to explore the biological/pharmacological properties and molecular mechanisms to better understand the beneficial and multiple health benefits of morin hydrate. Indeed, Morin hydrate exerts free radical scavenging, antioxidant, anti-inflammatory, anti-cancerous, anti-microbial, antidiabetic, anti-arthritis, cardioprotective, neuroprotective, nephroprotective, and hepatoprotective effects. Moreover, morin hydrate exhibits its pharmacological activities by modulating various cellular signaling pathways such as Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-қB), Mitogen-activated protein kinase (MAPK), Janus kinases/ Signal transducer and activator of transcription proteins (JAKs/STATs), Kelch-like ECH-associated protein1/Nuclear erythroid-2-related factor (Keap1/Nrf2), Endoplasmic reticulum (ER), Mitochondrial-mediated apoptosis, Wnt/β-catenin, and Mechanistic target of rapamycin (mTOR). Most importantly, morin hydrate has the potential to modulate a variety of biological networks. Therefore, it can be predicted that this therapeutically potent compound could serve as a dietary agent for the expansion of human health and might be helpful for the development of the novel drug in the future. However, due to the lack of clinical trials, special human clinical trials are needed to address the effects of morin hydrate on various life-threatening disparities to recommend morin and/or morin-rich foods with other foods or bioactive dietary components, as well as dose-response interaction and safety profile.

Authors+Show Affiliations

College of Animal Science, South China Agricultural University/Guangdong Laboratory for Lingnan Modern Agriculture/Guangdong Provincial Key Laboratory of Animal Nutrition Control/National Engineering Research Center for Breeding Swine Industry, Guangzhou, Guangdong, China.College of Animal Science, South China Agricultural University/Guangdong Laboratory for Lingnan Modern Agriculture/Guangdong Provincial Key Laboratory of Animal Nutrition Control/National Engineering Research Center for Breeding Swine Industry, Guangzhou, Guangdong, China. Electronic address: xqwang@scau.edu.cn.College of Animal Science, South China Agricultural University/Guangdong Laboratory for Lingnan Modern Agriculture/Guangdong Provincial Key Laboratory of Animal Nutrition Control/National Engineering Research Center for Breeding Swine Industry, Guangzhou, Guangdong, China. Electronic address: yanhc@scau.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33744757

Citation

Rajput, Shahid Ali, et al. "Morin Hydrate: a Comprehensive Review On Novel Natural Dietary Bioactive Compound With Versatile Biological and Pharmacological Potential." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 138, 2021, p. 111511.
Rajput SA, Wang XQ, Yan HC. Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential. Biomed Pharmacother. 2021;138:111511.
Rajput, S. A., Wang, X. Q., & Yan, H. C. (2021). Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 138, 111511. https://doi.org/10.1016/j.biopha.2021.111511
Rajput SA, Wang XQ, Yan HC. Morin Hydrate: a Comprehensive Review On Novel Natural Dietary Bioactive Compound With Versatile Biological and Pharmacological Potential. Biomed Pharmacother. 2021;138:111511. PubMed PMID: 33744757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential. AU - Rajput,Shahid Ali, AU - Wang,Xiu-Qi, AU - Yan,Hui-Chao, Y1 - 2021/03/18/ PY - 2021/02/03/received PY - 2021/03/07/revised PY - 2021/03/11/accepted PY - 2021/3/22/pubmed PY - 2021/7/24/medline PY - 2021/3/21/entrez KW - Anti-cancer KW - Anti-inflammatory KW - Anti-microbial KW - Antioxidant KW - Bioactive compound KW - Cardioprotective KW - Morin hydrate KW - Neuroprotective SP - 111511 EP - 111511 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 138 N2 - Flavonoids are natural plant-derived dietary bioactive compounds having a substantial impact on human health. Morin hydrate is a bioflavonoid mainly obtained from fruits, stem, and leaves of Moraceae family members' plants. Plenty of evidences supported that morin hydrate exerts its beneficial effects against various chronic and life-threatening degenerative diseases. Our current article discloses the recent advances that have been studied to explore the biological/pharmacological properties and molecular mechanisms to better understand the beneficial and multiple health benefits of morin hydrate. Indeed, Morin hydrate exerts free radical scavenging, antioxidant, anti-inflammatory, anti-cancerous, anti-microbial, antidiabetic, anti-arthritis, cardioprotective, neuroprotective, nephroprotective, and hepatoprotective effects. Moreover, morin hydrate exhibits its pharmacological activities by modulating various cellular signaling pathways such as Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-қB), Mitogen-activated protein kinase (MAPK), Janus kinases/ Signal transducer and activator of transcription proteins (JAKs/STATs), Kelch-like ECH-associated protein1/Nuclear erythroid-2-related factor (Keap1/Nrf2), Endoplasmic reticulum (ER), Mitochondrial-mediated apoptosis, Wnt/β-catenin, and Mechanistic target of rapamycin (mTOR). Most importantly, morin hydrate has the potential to modulate a variety of biological networks. Therefore, it can be predicted that this therapeutically potent compound could serve as a dietary agent for the expansion of human health and might be helpful for the development of the novel drug in the future. However, due to the lack of clinical trials, special human clinical trials are needed to address the effects of morin hydrate on various life-threatening disparities to recommend morin and/or morin-rich foods with other foods or bioactive dietary components, as well as dose-response interaction and safety profile. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/33744757/Morin_hydrate:_A_comprehensive_review_on_novel_natural_dietary_bioactive_compound_with_versatile_biological_and_pharmacological_potential_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(21)00296-1 DB - PRIME DP - Unbound Medicine ER -