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Outcomes of newborns to mothers with COVID-19.
Infect Dis Now. 2021 Aug; 51(5):435-439.ID

Abstract

INTRODUCTION

Coronavirus disease 2019 (COVID-19) has spread rapidly across the world. Given the sharply increased infection rate, the number of pregnant women and children with COVID-19 is correspondingly on the rise. SARS-CoV-2 infection is transmitted through droplets; though hypothesized, other transmission routes have not been confirmed. As of now, it remains unclear whether and how SARS-CoV-2 can possibly be transmitted from the mother to the fetus.

METHOD

This study examines the medical records of 30 neonates born to women with COVID-19, the objective being to provide documented information on maternal-child transmission and infant outcomes.

RESULTS

Out of the 30 newborns, 28 had negative PCR test results for SARS-CoV-2; among their mothers, fifteen had fever, nine had cough and twenty had delivered by cesarean section. The median birth term was 37wk2dy, and twenty of the neonates were male. Most of them were asymptomatic, except for the three who presented with shortness of breath. Two of them were intubated and both died, the first because of severe sepsis and the second due to severe hyaline membrane disease. As regards the two infected neonates, the first represents a probable case of congenital SARS-CoV-2 infection, which appears unlikely in the second case. The outcome for both of them was good, without any complications.

CONCLUSION

Maternal-fetal transmission of the SARS- CoV-2 virus was not detected in the majority of the reported cases, although two of 30 neonates had positive qRT-PCR test results. Our study supports the hypothesis that though it seldom actually occurs, in utero SARS-CoV-2 vertical transmission is possible.

Authors+Show Affiliations

Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: Karima.ghema91@gmail.com.Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: lehlimimouna@gmail.com.Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: hanane.toumi@gmail.com.Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: badreamal@gmail.com.Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: mounirchemsi@yahoo.fr.Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: Abdohabzi@gmail.com.Department of Neonatology, Institute of Maternal and Child Health, Casablanca Children's Hospital, Casablanca, Morocco. Electronic address: S.benomar2@yahoo.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33748807

Citation

Ghema, K, et al. "Outcomes of Newborns to Mothers With COVID-19." Infectious Diseases Now, vol. 51, no. 5, 2021, pp. 435-439.
Ghema K, Lehlimi M, Toumi H, et al. Outcomes of newborns to mothers with COVID-19. Infect Dis Now. 2021;51(5):435-439.
Ghema, K., Lehlimi, M., Toumi, H., Badre, A., Chemsi, M., Habzi, A., & Benomar, S. (2021). Outcomes of newborns to mothers with COVID-19. Infectious Diseases Now, 51(5), 435-439. https://doi.org/10.1016/j.idnow.2021.03.003
Ghema K, et al. Outcomes of Newborns to Mothers With COVID-19. Infect Dis Now. 2021;51(5):435-439. PubMed PMID: 33748807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes of newborns to mothers with COVID-19. AU - Ghema,K, AU - Lehlimi,M, AU - Toumi,H, AU - Badre,A, AU - Chemsi,M, AU - Habzi,A, AU - Benomar,S, Y1 - 2021/03/17/ PY - 2021/02/15/received PY - 2021/02/26/revised PY - 2021/03/10/accepted PY - 2021/3/23/pubmed PY - 2021/8/12/medline PY - 2021/3/22/entrez KW - COVID-19 KW - Congenital transmission KW - Delivery KW - Mothers KW - Neonates SP - 435 EP - 439 JF - Infectious diseases now JO - Infect Dis Now VL - 51 IS - 5 N2 - INTRODUCTION: Coronavirus disease 2019 (COVID-19) has spread rapidly across the world. Given the sharply increased infection rate, the number of pregnant women and children with COVID-19 is correspondingly on the rise. SARS-CoV-2 infection is transmitted through droplets; though hypothesized, other transmission routes have not been confirmed. As of now, it remains unclear whether and how SARS-CoV-2 can possibly be transmitted from the mother to the fetus. METHOD: This study examines the medical records of 30 neonates born to women with COVID-19, the objective being to provide documented information on maternal-child transmission and infant outcomes. RESULTS: Out of the 30 newborns, 28 had negative PCR test results for SARS-CoV-2; among their mothers, fifteen had fever, nine had cough and twenty had delivered by cesarean section. The median birth term was 37wk2dy, and twenty of the neonates were male. Most of them were asymptomatic, except for the three who presented with shortness of breath. Two of them were intubated and both died, the first because of severe sepsis and the second due to severe hyaline membrane disease. As regards the two infected neonates, the first represents a probable case of congenital SARS-CoV-2 infection, which appears unlikely in the second case. The outcome for both of them was good, without any complications. CONCLUSION: Maternal-fetal transmission of the SARS- CoV-2 virus was not detected in the majority of the reported cases, although two of 30 neonates had positive qRT-PCR test results. Our study supports the hypothesis that though it seldom actually occurs, in utero SARS-CoV-2 vertical transmission is possible. SN - 2666-9919 UR - https://www.unboundmedicine.com/medline/citation/33748807/Outcomes_of_newborns_to_mothers_with_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2666-9919(21)00065-8 DB - PRIME DP - Unbound Medicine ER -