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[Antigliadin and antireticulin antibodies in juvenile insulin-dependent diabetes mellitus].
Pediatr Med Chir. 1988 Jan-Feb; 10(1):33-7.PM

Abstract

A total of 203 patients with insulin-dependent diabetes mellitus (IDDM) were screened for coeliac disease (CD) by means of serum IgA and IgG antigliadin (AGA) (ELISA) and total anti reticulin antibody (ARA) IFL assay. As suggested by Savilhati, the combination of the IgA and IgG AGA test with IgA titration in serum (to find IgA deficient individuals) identifies almost 100% of CD patients. In this study ARA antibody assay was performed and two new suspect coeliac cases were found among IgA AGA negative children. Together the ARA and AGA tests give a 3% overall prevalence of CD in IDDM. The confirmation of CD must still be obtained with jejunal biopsy. Even high titres of AGA IgG are less specific for coeliac disease and in IDDM may identify those patients who are immunologically more hyperreactive.

Authors+Show Affiliations

Istituto di Discipline Pediatriche dell'Università di Torino, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

3375126

Citation

Barbera, C, et al. "[Antigliadin and Antireticulin Antibodies in Juvenile Insulin-dependent Diabetes Mellitus]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 10, no. 1, 1988, pp. 33-7.
Barbera C, Fusco P, Gabetti L, et al. [Antigliadin and antireticulin antibodies in juvenile insulin-dependent diabetes mellitus]. Pediatr Med Chir. 1988;10(1):33-7.
Barbera, C., Fusco, P., Gabetti, L., Cerutti, F., & Sacchetti, C. (1988). [Antigliadin and antireticulin antibodies in juvenile insulin-dependent diabetes mellitus]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 10(1), 33-7.
Barbera C, et al. [Antigliadin and Antireticulin Antibodies in Juvenile Insulin-dependent Diabetes Mellitus]. Pediatr Med Chir. 1988;10(1):33-7. PubMed PMID: 3375126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antigliadin and antireticulin antibodies in juvenile insulin-dependent diabetes mellitus]. AU - Barbera,C, AU - Fusco,P, AU - Gabetti,L, AU - Cerutti,F, AU - Sacchetti,C, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 33 EP - 7 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 10 IS - 1 N2 - A total of 203 patients with insulin-dependent diabetes mellitus (IDDM) were screened for coeliac disease (CD) by means of serum IgA and IgG antigliadin (AGA) (ELISA) and total anti reticulin antibody (ARA) IFL assay. As suggested by Savilhati, the combination of the IgA and IgG AGA test with IgA titration in serum (to find IgA deficient individuals) identifies almost 100% of CD patients. In this study ARA antibody assay was performed and two new suspect coeliac cases were found among IgA AGA negative children. Together the ARA and AGA tests give a 3% overall prevalence of CD in IDDM. The confirmation of CD must still be obtained with jejunal biopsy. Even high titres of AGA IgG are less specific for coeliac disease and in IDDM may identify those patients who are immunologically more hyperreactive. SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/3375126/[Antigliadin_and_antireticulin_antibodies_in_juvenile_insulin_dependent_diabetes_mellitus]_ L2 - http://www.diseaseinfosearch.org/result/2242 DB - PRIME DP - Unbound Medicine ER -