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Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses.
J Infect Dis. 2021 07 02; 224(1):49-59.JI

Abstract

BACKGROUND

We investigated frequency of reinfection with seasonal human coronaviruses (HCoVs) and serum antibody response following infection over 8 years in the Household Influenza Vaccine Evaluation (HIVE) cohort.

METHODS

Households were followed annually for identification of acute respiratory illness with reverse-transcription polymerase chain reaction-confirmed HCoV infection. Serum collected before and at 2 time points postinfection were tested using a multiplex binding assay to quantify antibody to seasonal, severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins and SARS-CoV-2 spike subdomains and N protein.

RESULTS

Of 3418 participants, 40% were followed for ≥3 years. A total of 1004 HCoV infections were documented; 303 (30%) were reinfections of any HCoV type. The number of HCoV infections ranged from 1 to 13 per individual. The mean time to reinfection with the same type was estimated at 983 days for 229E, 578 days for HKU1, 615 days for OC43, and 711 days for NL63. Binding antibody levels to seasonal HCoVs were high, with little increase postinfection, and were maintained over time. Homologous, preinfection antibody levels did not significantly correlate with odds of infection, and there was little cross-response to SARS-CoV-2 proteins.

CONCLUSIONS

Reinfection with seasonal HCoVs is frequent. Binding anti-spike protein antibodies do not correlate with protection from seasonal HCoV infection.

Authors+Show Affiliations

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.Protein Expression Laboratory, National Cancer Institute RAS Initiative, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

33755731

Citation

Petrie, Joshua G., et al. "Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses." The Journal of Infectious Diseases, vol. 224, no. 1, 2021, pp. 49-59.
Petrie JG, Bazzi LA, McDermott AB, et al. Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses. J Infect Dis. 2021;224(1):49-59.
Petrie, J. G., Bazzi, L. A., McDermott, A. B., Follmann, D., Esposito, D., Hatcher, C., Mateja, A., Narpala, S. R., O'Connell, S. E., Martin, E. T., & Monto, A. S. (2021). Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses. The Journal of Infectious Diseases, 224(1), 49-59. https://doi.org/10.1093/infdis/jiab161
Petrie JG, et al. Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses. J Infect Dis. 2021 07 2;224(1):49-59. PubMed PMID: 33755731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus Occurrence in the Household Influenza Vaccine Evaluation (HIVE) Cohort of Michigan Households: Reinfection Frequency and Serologic Responses to Seasonal and Severe Acute Respiratory Syndrome Coronaviruses. AU - Petrie,Joshua G, AU - Bazzi,Latifa A, AU - McDermott,Adrian B, AU - Follmann,Dean, AU - Esposito,Dominic, AU - Hatcher,Christian, AU - Mateja,Allyson, AU - Narpala,Sandeep R, AU - O'Connell,Sarah E, AU - Martin,Emily T, AU - Monto,Arnold S, PY - 2021/02/24/received PY - 2021/03/19/accepted PY - 2021/3/24/pubmed PY - 2021/7/20/medline PY - 2021/3/23/entrez KW - COVID-19 KW - SARS-CoV-2 KW - antibody KW - correlates of protection KW - household cohort KW - immunity KW - reinfection KW - seasonal coronavirus KW - serology KW - waning SP - 49 EP - 59 JF - The Journal of infectious diseases JO - J Infect Dis VL - 224 IS - 1 N2 - BACKGROUND: We investigated frequency of reinfection with seasonal human coronaviruses (HCoVs) and serum antibody response following infection over 8 years in the Household Influenza Vaccine Evaluation (HIVE) cohort. METHODS: Households were followed annually for identification of acute respiratory illness with reverse-transcription polymerase chain reaction-confirmed HCoV infection. Serum collected before and at 2 time points postinfection were tested using a multiplex binding assay to quantify antibody to seasonal, severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins and SARS-CoV-2 spike subdomains and N protein. RESULTS: Of 3418 participants, 40% were followed for ≥3 years. A total of 1004 HCoV infections were documented; 303 (30%) were reinfections of any HCoV type. The number of HCoV infections ranged from 1 to 13 per individual. The mean time to reinfection with the same type was estimated at 983 days for 229E, 578 days for HKU1, 615 days for OC43, and 711 days for NL63. Binding antibody levels to seasonal HCoVs were high, with little increase postinfection, and were maintained over time. Homologous, preinfection antibody levels did not significantly correlate with odds of infection, and there was little cross-response to SARS-CoV-2 proteins. CONCLUSIONS: Reinfection with seasonal HCoVs is frequent. Binding anti-spike protein antibodies do not correlate with protection from seasonal HCoV infection. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/33755731/Coronavirus_Occurrence_in_the_Household_Influenza_Vaccine_Evaluation__HIVE__Cohort_of_Michigan_Households:_Reinfection_Frequency_and_Serologic_Responses_to_Seasonal_and_Severe_Acute_Respiratory_Syndrome_Coronaviruses_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiab161 DB - PRIME DP - Unbound Medicine ER -