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A single mRNA immunization boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.
medRxiv. 2021 Mar 10M

Abstract

Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies.

Authors

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Pub Type(s)

Preprint

Language

eng

PubMed ID

33758873

Citation

Stamatatos, Leonidas, et al. "A Single mRNA Immunization Boosts Cross-variant Neutralizing Antibodies Elicited By SARS-CoV-2 Infection." MedRxiv : the Preprint Server for Health Sciences, 2021.
Stamatatos L, Czartoski J, Wan YH, et al. A single mRNA immunization boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection. medRxiv. 2021.
Stamatatos, L., Czartoski, J., Wan, Y. H., Homad, L. J., Rubin, V., Glantz, H., Neradilek, M., Seydoux, E., Jennewein, M. F., MacCamy, A. J., Feng, J., Mize, G., De Rosa, S. C., Finzi, A., Lemos, M. P., Cohen, K. W., Moodie, Z., McElrath, M. J., & McGuire, A. T. (2021). A single mRNA immunization boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection. MedRxiv : the Preprint Server for Health Sciences. https://doi.org/10.1101/2021.02.05.21251182
Stamatatos L, et al. A Single mRNA Immunization Boosts Cross-variant Neutralizing Antibodies Elicited By SARS-CoV-2 Infection. medRxiv. 2021 Mar 10; PubMed PMID: 33758873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A single mRNA immunization boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection. AU - Stamatatos,Leonidas, AU - Czartoski,Julie, AU - Wan,Yu-Hsin, AU - Homad,Leah J, AU - Rubin,Vanessa, AU - Glantz,Hayley, AU - Neradilek,Moni, AU - Seydoux,Emilie, AU - Jennewein,Madeleine F, AU - MacCamy,Anna J, AU - Feng,Junli, AU - Mize,Gregory, AU - De Rosa,Stephen C, AU - Finzi,Andrés, AU - Lemos,Maria P, AU - Cohen,Kristen W, AU - Moodie,Zoe, AU - McElrath,M Juliana, AU - McGuire,Andrew T, Y1 - 2021/03/10/ PY - 2021/3/24/entrez PY - 2021/3/25/pubmed PY - 2021/3/25/medline JF - medRxiv : the preprint server for health sciences JO - medRxiv N2 - Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies. UR - https://www.unboundmedicine.com/medline/citation/33758873/A_single_mRNA_immunization_boosts_cross_variant_neutralizing_antibodies_elicited_by_SARS_CoV_2_infection_ L2 - https://doi.org/10.1101/2021.02.05.21251182 DB - PRIME DP - Unbound Medicine ER -
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