TY - JOUR T1 - Role of connexins in neurodegenerative diseases (Review). AU - Xing,Juping, AU - Xu,Changshui, Y1 - 2021/03/24/ PY - 2020/10/03/received PY - 2021/03/02/accepted PY - 2021/3/24/entrez PY - 2021/3/25/pubmed PY - 2021/5/8/medline KW - connexin KW - neurodegenerative disease KW - PD KW - AD KW - ALS KW - HD JF - Molecular medicine reports JO - Mol Med Rep VL - 23 IS - 5 N2 - Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. These changes may cause glia to lose their ability to support and protect neurons and induce abnormal increases in levels of ions and metabolites, such as calcium ions, glutamate and ATP, around neurons. These processes eventuallys lead to neuronal death. In the present review, the abnormal expression of connexin and its primary role in neurodegenerative diseases was investigated. SN - 1791-3004 UR - https://www.unboundmedicine.com/medline/citation/33760195/Role_of_connexins_in_neurodegenerative_diseases__Review__ DB - PRIME DP - Unbound Medicine ER -