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Role of connexins in neurodegenerative diseases (Review).
Mol Med Rep. 2021 05; 23(5)MM

Abstract

Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. These changes may cause glia to lose their ability to support and protect neurons and induce abnormal increases in levels of ions and metabolites, such as calcium ions, glutamate and ATP, around neurons. These processes eventuallys lead to neuronal death. In the present review, the abnormal expression of connexin and its primary role in neurodegenerative diseases was investigated.

Authors+Show Affiliations

Department of Physiology, Basic Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.Department of Physiology, Basic Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33760195

Citation

Xing, Juping, and Changshui Xu. "Role of Connexins in Neurodegenerative Diseases (Review)." Molecular Medicine Reports, vol. 23, no. 5, 2021.
Xing J, Xu C. Role of connexins in neurodegenerative diseases (Review). Mol Med Rep. 2021;23(5).
Xing, J., & Xu, C. (2021). Role of connexins in neurodegenerative diseases (Review). Molecular Medicine Reports, 23(5). https://doi.org/10.3892/mmr.2021.12034
Xing J, Xu C. Role of Connexins in Neurodegenerative Diseases (Review). Mol Med Rep. 2021;23(5) PubMed PMID: 33760195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of connexins in neurodegenerative diseases (Review). AU - Xing,Juping, AU - Xu,Changshui, Y1 - 2021/03/24/ PY - 2020/10/03/received PY - 2021/03/02/accepted PY - 2021/3/24/entrez PY - 2021/3/25/pubmed PY - 2021/5/8/medline KW - connexin KW - neurodegenerative disease KW - PD KW - AD KW - ALS KW - HD JF - Molecular medicine reports JO - Mol Med Rep VL - 23 IS - 5 N2 - Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. These changes may cause glia to lose their ability to support and protect neurons and induce abnormal increases in levels of ions and metabolites, such as calcium ions, glutamate and ATP, around neurons. These processes eventuallys lead to neuronal death. In the present review, the abnormal expression of connexin and its primary role in neurodegenerative diseases was investigated. SN - 1791-3004 UR - https://www.unboundmedicine.com/medline/citation/33760195/Role_of_connexins_in_neurodegenerative_diseases__Review__ DB - PRIME DP - Unbound Medicine ER -