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Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study.
Trans R Soc Trop Med Hyg. 2021 05 08; 115(5):551-556.TR

Abstract

BACKGROUND

There is a paucity of data on risk factors for infection among healthcare workers (HCWs) from India. Our objective was to evaluate the risk factors and frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among HCWs.

METHODS

We conducted this retrospective case-control study of 3100 HCWs between May and July 2020. HCWs positive for SARS-CoV-2 infection were the cases (n=506) and those negative for SARS-CoV-2 were the controls (n=253). Univariate analysis was followed by multivariate analysis of key demographic, clinical and infection control variables.

RESULTS

SARS-CoV-2 infection was found in 16.32% of HCWs. Nearly 45% of infected HCWs were asymptomatic. The proportions of sanitation workers (24% vs 8%; p<0.0001) and technicians (10% vs 4%; p=0.0002) were higher and that of doctors was lower among cases as compared with controls (23% vs 43%; p<0.0001). On univariate analysis, the type of HCW, smoking, lack of training, inadequate personal protective equipment (PPE) use and taking no or fewer doses of hydroxychloroquine (HCQ) were found to be significant. On multivariate analysis, the type of HCW (risk ratio [RR] 1.67 [95% confidence interval {CI} 1.34 to 2.08], p<0.0001), inappropriate PPE use (RR 0.63 [95% CI 0.44 to 0.89], p=0.01) and taking fewer doses of HCQ (RR 0.92 [95% CI 0.86 to 0.99], p=0.03) were significant.

CONCLUSIONS

The frequency of SARS-CoV-2 infection was 16% among HCWs. Being a sanitation worker, inappropriate PPE use and lack of HCQ prophylaxis predisposed HCWs to SARS-CoV-2 infection.

Authors+Show Affiliations

Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.Department of Pulmonology and Critical Care, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.Department of Pediatrics, All India Institute of Medical Sciences, Delhi, India 110029.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33763687

Citation

Dev, Nishanth, et al. "Risk Factors and Frequency of COVID-19 Among Healthcare Workers at a Tertiary Care Centre in India: a Case-control Study." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 115, no. 5, 2021, pp. 551-556.
Dev N, Meena RC, Gupta DK, et al. Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study. Trans R Soc Trop Med Hyg. 2021;115(5):551-556.
Dev, N., Meena, R. C., Gupta, D. K., Gupta, N., & Sankar, J. (2021). Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115(5), 551-556. https://doi.org/10.1093/trstmh/trab047
Dev N, et al. Risk Factors and Frequency of COVID-19 Among Healthcare Workers at a Tertiary Care Centre in India: a Case-control Study. Trans R Soc Trop Med Hyg. 2021 05 8;115(5):551-556. PubMed PMID: 33763687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study. AU - Dev,Nishanth, AU - Meena,Ramesh Chand, AU - Gupta,D K, AU - Gupta,Nitesh, AU - Sankar,Jhuma, PY - 2020/11/23/received PY - 2021/02/15/revised PY - 2021/03/03/accepted PY - 2021/3/26/pubmed PY - 2021/5/28/medline PY - 2021/3/25/entrez KW - COVID-19 KW - HCQ KW - PPE KW - SARS-CoV-2 infection KW - healthcare worker KW - hydroxychloroquine KW - personal protective equipment SP - 551 EP - 556 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 115 IS - 5 N2 - BACKGROUND: There is a paucity of data on risk factors for infection among healthcare workers (HCWs) from India. Our objective was to evaluate the risk factors and frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among HCWs. METHODS: We conducted this retrospective case-control study of 3100 HCWs between May and July 2020. HCWs positive for SARS-CoV-2 infection were the cases (n=506) and those negative for SARS-CoV-2 were the controls (n=253). Univariate analysis was followed by multivariate analysis of key demographic, clinical and infection control variables. RESULTS: SARS-CoV-2 infection was found in 16.32% of HCWs. Nearly 45% of infected HCWs were asymptomatic. The proportions of sanitation workers (24% vs 8%; p<0.0001) and technicians (10% vs 4%; p=0.0002) were higher and that of doctors was lower among cases as compared with controls (23% vs 43%; p<0.0001). On univariate analysis, the type of HCW, smoking, lack of training, inadequate personal protective equipment (PPE) use and taking no or fewer doses of hydroxychloroquine (HCQ) were found to be significant. On multivariate analysis, the type of HCW (risk ratio [RR] 1.67 [95% confidence interval {CI} 1.34 to 2.08], p<0.0001), inappropriate PPE use (RR 0.63 [95% CI 0.44 to 0.89], p=0.01) and taking fewer doses of HCQ (RR 0.92 [95% CI 0.86 to 0.99], p=0.03) were significant. CONCLUSIONS: The frequency of SARS-CoV-2 infection was 16% among HCWs. Being a sanitation worker, inappropriate PPE use and lack of HCQ prophylaxis predisposed HCWs to SARS-CoV-2 infection. SN - 1878-3503 UR - https://www.unboundmedicine.com/medline/citation/33763687/Risk_factors_and_frequency_of_COVID_19_among_healthcare_workers_at_a_tertiary_care_centre_in_India:_a_case_control_study_ L2 - https://academic.oup.com/trstmh/article-lookup/doi/10.1093/trstmh/trab047 DB - PRIME DP - Unbound Medicine ER -