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Etiology, pathogenesis and management of idiopathic intracranial hypertension, and role of optic canal size in asymmetric papilledema: A review.
Eur J Ophthalmol. 2021 May; 31(3):892-903.EJ

Abstract

Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure of unknown origin that primarily afflicts obese women of childbearing age. There are several treatment options, but currently there are none that are effective for the entire affected population. The lack of a universally effective treatment is related to an incomplete understanding of the etiology of the condition and the lack of a well-defined pathophysiological mechanism for the disease process. Classically, IIH has been thought of as a diagnosis of exclusion once radiographical imaging has ruled out all other causes of elevated intracranial pressure. Today, we know that imaging does capture subtle changes, and might provide keys to finally understand the pathogenesis of IIH so that a definitive treatment can be discovered or developed. Recently, advancements in radiography, optical coherence tomography, and electroretinography have shown promise for the future of IIH evaluation. A topic within IIH imaging that has recently sparked interest is the possibility that the severity of papilledema may have an association with the size of the optic canal. In this article, we also discuss the recent studies on the relationship between asymmetric papilledema and optic canal size.

Authors+Show Affiliations

Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.Icahn School of Medicine at Mount Sinai, New York, NY, USA.Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA. Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA. Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, IN, USA.Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33779328

Citation

Mitchell, Chandler, et al. "Etiology, Pathogenesis and Management of Idiopathic Intracranial Hypertension, and Role of Optic Canal Size in Asymmetric Papilledema: a Review." European Journal of Ophthalmology, vol. 31, no. 3, 2021, pp. 892-903.
Mitchell C, Mathew S, Harris A, et al. Etiology, pathogenesis and management of idiopathic intracranial hypertension, and role of optic canal size in asymmetric papilledema: A review. Eur J Ophthalmol. 2021;31(3):892-903.
Mitchell, C., Mathew, S., Harris, A., Lang, M., Mackay, D., & Kovoor, J. (2021). Etiology, pathogenesis and management of idiopathic intracranial hypertension, and role of optic canal size in asymmetric papilledema: A review. European Journal of Ophthalmology, 31(3), 892-903. https://doi.org/10.1177/11206721211005709
Mitchell C, et al. Etiology, Pathogenesis and Management of Idiopathic Intracranial Hypertension, and Role of Optic Canal Size in Asymmetric Papilledema: a Review. Eur J Ophthalmol. 2021;31(3):892-903. PubMed PMID: 33779328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology, pathogenesis and management of idiopathic intracranial hypertension, and role of optic canal size in asymmetric papilledema: A review. AU - Mitchell,Chandler, AU - Mathew,Sunu, AU - Harris,Alon, AU - Lang,Matthew, AU - Mackay,Devin, AU - Kovoor,Jerry, Y1 - 2021/03/28/ PY - 2021/3/30/pubmed PY - 2021/8/20/medline PY - 2021/3/29/entrez KW - Idiopathic intracranial hypertension KW - asymmetric papilledema KW - optic canal size SP - 892 EP - 903 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 31 IS - 3 N2 - Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure of unknown origin that primarily afflicts obese women of childbearing age. There are several treatment options, but currently there are none that are effective for the entire affected population. The lack of a universally effective treatment is related to an incomplete understanding of the etiology of the condition and the lack of a well-defined pathophysiological mechanism for the disease process. Classically, IIH has been thought of as a diagnosis of exclusion once radiographical imaging has ruled out all other causes of elevated intracranial pressure. Today, we know that imaging does capture subtle changes, and might provide keys to finally understand the pathogenesis of IIH so that a definitive treatment can be discovered or developed. Recently, advancements in radiography, optical coherence tomography, and electroretinography have shown promise for the future of IIH evaluation. A topic within IIH imaging that has recently sparked interest is the possibility that the severity of papilledema may have an association with the size of the optic canal. In this article, we also discuss the recent studies on the relationship between asymmetric papilledema and optic canal size. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/33779328/Etiology_pathogenesis_and_management_of_idiopathic_intracranial_hypertension_and_role_of_optic_canal_size_in_asymmetric_papilledema:_A_review_ L2 - https://journals.sagepub.com/doi/10.1177/11206721211005709?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -