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Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials.
Complement Ther Med. 2021 Jun; 59:102715.CT

Abstract

BACKGROUND

Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.

METHODS AND MATERIALS

A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered in PROSPERO (No. CRD42020166053).

RESULTS

This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95 % CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95 % CI: -0.12, 0.08; p = 0.715).

CONCLUSION

Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.

Authors+Show Affiliations

Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: Gholamia1@nums.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

33785457

Citation

Hariri, Mitra, et al. "Beneficial Effect of Soy Isoflavones and Soy Isoflavones Plus Soy Protein On Serum Concentration of C-reactive Protein Among Postmenopausal Women: an Updated Systematic Review and Meta-analysis of Randomized Controlled Trials." Complementary Therapies in Medicine, vol. 59, 2021, p. 102715.
Hariri M, Ghasemi A, Baradaran HR, et al. Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2021;59:102715.
Hariri, M., Ghasemi, A., Baradaran, H. R., Mollanoroozy, E., & Gholami, A. (2021). Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 59, 102715. https://doi.org/10.1016/j.ctim.2021.102715
Hariri M, et al. Beneficial Effect of Soy Isoflavones and Soy Isoflavones Plus Soy Protein On Serum Concentration of C-reactive Protein Among Postmenopausal Women: an Updated Systematic Review and Meta-analysis of Randomized Controlled Trials. Complement Ther Med. 2021;59:102715. PubMed PMID: 33785457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials. AU - Hariri,Mitra, AU - Ghasemi,Ahmad, AU - Baradaran,Hamid Reza, AU - Mollanoroozy,Ensieyh, AU - Gholami,Ali, Y1 - 2021/03/27/ PY - 2020/11/29/received PY - 2021/02/27/revised PY - 2021/03/24/accepted PY - 2021/4/1/pubmed PY - 2021/11/25/medline PY - 2021/3/31/entrez KW - C-reactive protein KW - Postmenopausal women KW - Soy isoflavones KW - Soy protein SP - 102715 EP - 102715 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 59 N2 - BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed. METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered in PROSPERO (No. CRD42020166053). RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95 % CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95 % CI: -0.12, 0.08; p = 0.715). CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/33785457/Beneficial_effect_of_soy_isoflavones_and_soy_isoflavones_plus_soy_protein_on_serum_concentration_of_C_reactive_protein_among_postmenopausal_women:_An_updated_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(21)00056-X DB - PRIME DP - Unbound Medicine ER -