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Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans.
Commun Biol. 2021 Mar 31; 4(1):436.CB

Abstract

Bodies have continuous reticular networks, comprising collagens, elastin, glycosaminoglycans, and other extracellular matrix components, through all tissues and organs. Fibrous coverings of nerves and blood vessels create structural continuity beyond organ boundaries. We recently validated fluid flow through human fibrous tissues, though whether these interstitial spaces are continuous through the body or discontinuous, confined within individual organs, remains unclear. Here we show evidence for continuity of interstitial spaces using two approaches. Non-biological particles (tattoo pigment, colloidal silver) were tracked within colon and skin interstitial spaces and into adjacent fascia. Hyaluronic acid, a macromolecular component of interstitial spaces, was also visualized. Both techniques demonstrate interstitial continuity within and between organs including within perineurium and vascular adventitia traversing organs and the spaces between them. We suggest that there is a body-wide network of fluid-filled interstitial spaces that has significant implications for molecular signaling, cell trafficking, and the spread of malignant and infectious disease.

Authors+Show Affiliations

Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Divison of Gastroenterology and Hepatology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.Department of Pathology, Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.Divison of Gastroenterology and Hepatology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Department of Bioengineering, School of Engineering and Applied Sciences, The University of Pennsylvania, Philadelphia, PA, USA. Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Center for Engineering MechanoBiology, The University of Pennsylvania, Philadelphia, PA, USA.Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. neil.theise@nyulangone.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33790388

Citation

Cenaj, Odise, et al. "Evidence for Continuity of Interstitial Spaces Across Tissue and Organ Boundaries in Humans." Communications Biology, vol. 4, no. 1, 2021, p. 436.
Cenaj O, Allison DHR, Imam R, et al. Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans. Commun Biol. 2021;4(1):436.
Cenaj, O., Allison, D. H. R., Imam, R., Zeck, B., Drohan, L. M., Chiriboga, L., Llewellyn, J., Liu, C. Z., Park, Y. N., Wells, R. G., & Theise, N. D. (2021). Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans. Communications Biology, 4(1), 436. https://doi.org/10.1038/s42003-021-01962-0
Cenaj O, et al. Evidence for Continuity of Interstitial Spaces Across Tissue and Organ Boundaries in Humans. Commun Biol. 2021 Mar 31;4(1):436. PubMed PMID: 33790388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans. AU - Cenaj,Odise, AU - Allison,Douglas H R, AU - Imam,Rami, AU - Zeck,Briana, AU - Drohan,Lilly M, AU - Chiriboga,Luis, AU - Llewellyn,Jessica, AU - Liu,Cheng Z, AU - Park,Young Nyun, AU - Wells,Rebecca G, AU - Theise,Neil D, Y1 - 2021/03/31/ PY - 2020/08/06/received PY - 2021/03/02/accepted PY - 2021/4/1/entrez PY - 2021/4/2/pubmed PY - 2021/4/2/medline SP - 436 EP - 436 JF - Communications biology JO - Commun Biol VL - 4 IS - 1 N2 - Bodies have continuous reticular networks, comprising collagens, elastin, glycosaminoglycans, and other extracellular matrix components, through all tissues and organs. Fibrous coverings of nerves and blood vessels create structural continuity beyond organ boundaries. We recently validated fluid flow through human fibrous tissues, though whether these interstitial spaces are continuous through the body or discontinuous, confined within individual organs, remains unclear. Here we show evidence for continuity of interstitial spaces using two approaches. Non-biological particles (tattoo pigment, colloidal silver) were tracked within colon and skin interstitial spaces and into adjacent fascia. Hyaluronic acid, a macromolecular component of interstitial spaces, was also visualized. Both techniques demonstrate interstitial continuity within and between organs including within perineurium and vascular adventitia traversing organs and the spaces between them. We suggest that there is a body-wide network of fluid-filled interstitial spaces that has significant implications for molecular signaling, cell trafficking, and the spread of malignant and infectious disease. SN - 2399-3642 UR - https://www.unboundmedicine.com/medline/citation/33790388/Evidence_for_continuity_of_interstitial_spaces_across_tissue_and_organ_boundaries_in_humans. L2 - https://doi.org/10.1038/s42003-021-01962-0 DB - PRIME DP - Unbound Medicine ER -
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