Tags

Type your tag names separated by a space and hit enter

Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids.
Front Endocrinol (Lausanne). 2021; 12:626842.FE

Abstract

Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells. Their local and systemic production and accumulation is associated with the etiology and progression of several inflammatory diseases, but the molecular mechanisms that underlie the biological activities of these oxidized phospholipids remain elusive. Increasing evidence highlights the ability of these stress mediators to modulate cellular metabolism and pro-inflammatory signaling in phagocytes, such as macrophages and dendritic cells, and to alter the activation and polarization of these cells. Because these immune cells serve a key role in maintaining tissue homeostasis and organ function, understanding how endogenous oxidized lipids reshape phagocyte biology and function is vital for designing clinical tools and interventions for preventing, slowing down, or resolving chronic inflammatory disorders that are driven by phagocyte dysfunction. Here, we discuss the metabolic and signaling processes elicited by endogenous oxidized lipids and outline new hypotheses and models to elucidate the impact of these lipids on phagocytes and inflammation.

Authors+Show Affiliations

Division of Immunology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States.Division of Immunology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States. Division of Gastroenterology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

33790857

Citation

Di Gioia, Marco, and Ivan Zanoni. "Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids." Frontiers in Endocrinology, vol. 12, 2021, p. 626842.
Di Gioia M, Zanoni I. Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids. Front Endocrinol (Lausanne). 2021;12:626842.
Di Gioia, M., & Zanoni, I. (2021). Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids. Frontiers in Endocrinology, 12, 626842. https://doi.org/10.3389/fendo.2021.626842
Di Gioia M, Zanoni I. Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids. Front Endocrinol (Lausanne). 2021;12:626842. PubMed PMID: 33790857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids. AU - Di Gioia,Marco, AU - Zanoni,Ivan, Y1 - 2021/03/15/ PY - 2020/11/06/received PY - 2021/02/19/accepted PY - 2021/4/1/entrez PY - 2021/4/2/pubmed PY - 2021/4/23/medline KW - COVID-19 KW - atherosclerosis KW - immunometabolism KW - inflammasome KW - inflammation KW - lung KW - oxPAPC KW - oxidized phospholipids SP - 626842 EP - 626842 JF - Frontiers in endocrinology JO - Front Endocrinol (Lausanne) VL - 12 N2 - Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells. Their local and systemic production and accumulation is associated with the etiology and progression of several inflammatory diseases, but the molecular mechanisms that underlie the biological activities of these oxidized phospholipids remain elusive. Increasing evidence highlights the ability of these stress mediators to modulate cellular metabolism and pro-inflammatory signaling in phagocytes, such as macrophages and dendritic cells, and to alter the activation and polarization of these cells. Because these immune cells serve a key role in maintaining tissue homeostasis and organ function, understanding how endogenous oxidized lipids reshape phagocyte biology and function is vital for designing clinical tools and interventions for preventing, slowing down, or resolving chronic inflammatory disorders that are driven by phagocyte dysfunction. Here, we discuss the metabolic and signaling processes elicited by endogenous oxidized lipids and outline new hypotheses and models to elucidate the impact of these lipids on phagocytes and inflammation. SN - 1664-2392 UR - https://www.unboundmedicine.com/medline/citation/33790857/Dooming_Phagocyte_Responses:_Inflammatory_Effects_of_Endogenous_Oxidized_Phospholipids_ L2 - https://doi.org/10.3389/fendo.2021.626842 DB - PRIME DP - Unbound Medicine ER -