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Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020.
Euro Surveill. 2021 04; 26(13)ES

Abstract

BackgroundChildren have a low rate of COVID-19 and secondary severe multisystem inflammatory syndrome (MIS) but present a high prevalence of symptomatic seasonal coronavirus infections.AimWe tested if prior infections by seasonal coronaviruses (HCoV) NL63, HKU1, 229E or OC43 as assessed by serology, provide cross-protective immunity against SARS-CoV-2 infection.MethodsWe set a cross-sectional observational multicentric study in pauci- or asymptomatic children hospitalised in Paris during the first wave for reasons other than COVID (hospitalised children (HOS), n = 739) plus children presenting with MIS (n = 36). SARS-CoV-2 antibodies directed against the nucleoprotein (N) and S1 and S2 domains of the spike (S) proteins were monitored by an in-house luciferase immunoprecipitation system assay. We randomly selected 69 SARS-CoV-2-seropositive patients (including 15 with MIS) and 115 matched SARS-CoV-2-seronegative patients (controls (CTL)). We measured antibodies against SARS-CoV-2 and HCoV as evidence for prior corresponding infections and assessed if SARS-CoV-2 prevalence of infection and levels of antibody responses were shaped by prior seasonal coronavirus infections.ResultsPrevalence of HCoV infections were similar in HOS, MIS and CTL groups. Antibody levels against HCoV were not significantly different in the three groups and were not related to the level of SARS-CoV-2 antibodies in the HOS and MIS groups. SARS-CoV-2 antibody profiles were different between HOS and MIS children.ConclusionPrior infection by seasonal coronaviruses, as assessed by serology, does not interfere with SARS-CoV-2 infection and related MIS in children.

Authors+Show Affiliations

These authors contributed equally to the work. Université de Paris, Paris, France. Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France. Institut Necker Enfants Malades, INSERM U 1171, Paris, France.Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France. These authors contributed equally to the work.Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France. Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.Centre for Research in Epidemiology and Population Health, INSERM UMR1018, Villejuif, France. Hôpital Antoine Beclere, Clamart, France.Hub de Bioinformatique et Biostatistique - Département Biologie Computationnelle, Institut Pasteur, USR 3756 CNRS, Paris, France. Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.Université de Lyon, INRAE, VetAgro Sup, Usc 1233 UR RS2GP, Marcy l'Etoile, France. Université de Lyon, INRAE, VetAgro Sup, UMR EPIA, Marcy l'Etoile, France. Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Saint-Genès-Champanelle, France.Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.Unité de Virologie Structurale, Institut Pasteur, Département de Virologie, CNRS, UMR3569, Paris, France.Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France. Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France. Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.Hôpital Jean Verdier, Bondy, France.Hôpital Louis Mourier, Colombes, France.Hôpital Ambroise Paré, Boulogne Billancourt, France.Hôpital Robert Debré, Paris, France.Hôpital Kremlin Bicêtre, Le Kremlin-Bicêtre, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Armand Trousseau, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Hôpital Louis Mourier, Colombes, France.Plateforme de microbiologie mutualisée (P2M), Pasteur International Bioresources Network (PIBnet), Institut Pasteur, Paris, France. National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France. Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.Unité Biodiversité et Epidemiologie des Bacteries Pathogènes, Institut Pasteur, Paris, France. Université de Paris, Paris, France. Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Paris, France.Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France. Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.Ecole Nationale Vétérinaire d'Alfort, Maisons Alfort, France. Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33797390

Citation

Sermet-Gaudelus, Isabelle, et al. "Prior Infection By Seasonal Coronaviruses, as Assessed By Serology, Does Not Prevent SARS-CoV-2 Infection and Disease in Children, France, April to June 2020." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 26, no. 13, 2021.
Sermet-Gaudelus I, Temmam S, Huon C, et al. Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020. Euro Surveill. 2021;26(13).
Sermet-Gaudelus, I., Temmam, S., Huon, C., Behillil, S., Gajdos, V., Bigot, T., Lurier, T., Chrétien, D., Backovic, M., Delaunay-Moisan, A., Donati, F., Albert, M., Foucaud, E., Mesplées, B., Benoist, G., Faye, A., Duval-Arnould, M., Cretolle, C., Charbit, M., ... Eloit, M. (2021). Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 26(13). https://doi.org/10.2807/1560-7917.ES.2021.26.13.2001782
Sermet-Gaudelus I, et al. Prior Infection By Seasonal Coronaviruses, as Assessed By Serology, Does Not Prevent SARS-CoV-2 Infection and Disease in Children, France, April to June 2020. Euro Surveill. 2021;26(13) PubMed PMID: 33797390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020. AU - Sermet-Gaudelus,Isabelle, AU - Temmam,Sarah, AU - Huon,Christèle, AU - Behillil,Sylvie, AU - Gajdos,Vincent, AU - Bigot,Thomas, AU - Lurier,Thibaut, AU - Chrétien,Delphine, AU - Backovic,Marija, AU - Delaunay-Moisan,Agnès, AU - Donati,Flora, AU - Albert,Mélanie, AU - Foucaud,Elsa, AU - Mesplées,Bettina, AU - Benoist,Grégoire, AU - Faye,Albert, AU - Duval-Arnould,Marc, AU - Cretolle,Célia, AU - Charbit,Marina, AU - Aubart,Mélodie, AU - Auriau,Johanne, AU - Lorrot,Mathie, AU - Kariyawasam,Dulanjalee, AU - Fertitta,Laura, AU - Orliaguet,Gilles, AU - Pigneur,Bénédicte, AU - Bader-Meunier,Brigitte, AU - Briand,Coralie, AU - Enouf,Vincent, AU - Toubiana,Julie, AU - Guilleminot,Tiffany, AU - van der Werf,Sylvie, AU - Leruez-Ville,Marianne, AU - Eloit,Marc, PY - 2021/4/2/entrez PY - 2021/4/3/pubmed PY - 2021/4/10/medline KW - 229E KW - COVID-19 KW - HKU1 KW - NL63 KW - OC43 KW - SARS-CoV-2 JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 26 IS - 13 N2 - BackgroundChildren have a low rate of COVID-19 and secondary severe multisystem inflammatory syndrome (MIS) but present a high prevalence of symptomatic seasonal coronavirus infections.AimWe tested if prior infections by seasonal coronaviruses (HCoV) NL63, HKU1, 229E or OC43 as assessed by serology, provide cross-protective immunity against SARS-CoV-2 infection.MethodsWe set a cross-sectional observational multicentric study in pauci- or asymptomatic children hospitalised in Paris during the first wave for reasons other than COVID (hospitalised children (HOS), n = 739) plus children presenting with MIS (n = 36). SARS-CoV-2 antibodies directed against the nucleoprotein (N) and S1 and S2 domains of the spike (S) proteins were monitored by an in-house luciferase immunoprecipitation system assay. We randomly selected 69 SARS-CoV-2-seropositive patients (including 15 with MIS) and 115 matched SARS-CoV-2-seronegative patients (controls (CTL)). We measured antibodies against SARS-CoV-2 and HCoV as evidence for prior corresponding infections and assessed if SARS-CoV-2 prevalence of infection and levels of antibody responses were shaped by prior seasonal coronavirus infections.ResultsPrevalence of HCoV infections were similar in HOS, MIS and CTL groups. Antibody levels against HCoV were not significantly different in the three groups and were not related to the level of SARS-CoV-2 antibodies in the HOS and MIS groups. SARS-CoV-2 antibody profiles were different between HOS and MIS children.ConclusionPrior infection by seasonal coronaviruses, as assessed by serology, does not interfere with SARS-CoV-2 infection and related MIS in children. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/33797390/Prior_infection_by_seasonal_coronaviruses_as_assessed_by_serology_does_not_prevent_SARS_CoV_2_infection_and_disease_in_children_France_April_to_June_2020_ L2 - http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.13.2001782 DB - PRIME DP - Unbound Medicine ER -