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Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.
Emerg Infect Dis. 2021 May; 27(5):1446-1453.EI

Abstract

The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

33797393

Citation

Fintelman-Rodrigues, Natalia, et al. "Genetic Evidence and Host Immune Response in Persons Reinfected With SARS-CoV-2, Brazil." Emerging Infectious Diseases, vol. 27, no. 5, 2021, pp. 1446-1453.
Fintelman-Rodrigues N, da Silva APD, Dos Santos MC, et al. Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. Emerg Infect Dis. 2021;27(5):1446-1453.
Fintelman-Rodrigues, N., da Silva, A. P. D., Dos Santos, M. C., Saraiva, F. B., Ferreira, M. A., Gesto, J., Rodrigues, D. A. S., Vale, A. M., de Azevedo, I. G., Soares, V. C., Jiang, H., Tan, H., Tschoeke, D. A., Sacramento, C. Q., Bozza, F. A., Morel, C. M., Bozza, P. T., & Souza, T. M. L. (2021). Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. Emerging Infectious Diseases, 27(5), 1446-1453. https://doi.org/10.3201/eid2705.204912
Fintelman-Rodrigues N, et al. Genetic Evidence and Host Immune Response in Persons Reinfected With SARS-CoV-2, Brazil. Emerg Infect Dis. 2021;27(5):1446-1453. PubMed PMID: 33797393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil. AU - Fintelman-Rodrigues,Natalia, AU - da Silva,Aline P D, AU - Dos Santos,Monique Cristina, AU - Saraiva,Felipe B, AU - Ferreira,Marcelo A, AU - Gesto,João, AU - Rodrigues,Danielle A S, AU - Vale,André M, AU - de Azevedo,Isaclaudia G, AU - Soares,Vinícius C, AU - Jiang,Hui, AU - Tan,Hongdong, AU - Tschoeke,Diogo A, AU - Sacramento,Carolina Q, AU - Bozza,Fernando A, AU - Morel,Carlos M, AU - Bozza,Patrícia T, AU - Souza,Thiago Moreno L, Y1 - 2021/04/12/ PY - 2021/4/3/pubmed PY - 2021/4/3/medline PY - 2021/4/2/entrez KW - Brazil KW - COVID-19 KW - SARS-CoV-2 KW - coronavirus disease KW - humoral response KW - next-generation sequencing KW - reinfection KW - respiratory infections KW - severe acute respiratory syndrome coronavirus 2 KW - viruses KW - zoonoses SP - 1446 EP - 1453 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 27 IS - 5 N2 - The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/33797393/Genetic_Evidence_and_Host_Immune_Response_in_Persons_Reinfected_with_SARS_CoV_2_Brazil_ L2 - https://doi.org/10.3201/eid2705.204912 DB - PRIME DP - Unbound Medicine ER -