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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis.
Int J Mol Sci. 2021 Mar 08; 22(5)IJ

Abstract

Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle-Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

Authors+Show Affiliations

Academic Unit of Translational Medical Sciences, School of Medicine, Royal Derby Hospital Centre, University of Nottingham, Derby DE22 3DT, UK. Faculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.University Hospitals of Derby and Burton NHS Foundation Trust, Library & Knowledge Service, Derby DE22 3NT, UK.Faculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.Faculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.Faculty of Medicine, Obstetrics and Gynaecology, University of Minia, Minia 61519, Egypt.Academic Unit of Translational Medical Sciences, School of Medicine, Royal Derby Hospital Centre, University of Nottingham, Derby DE22 3DT, UK.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33800490

Citation

Aboeldalyl, Shaimaa, et al. "The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis." International Journal of Molecular Sciences, vol. 22, no. 5, 2021.
Aboeldalyl S, James C, Seyam E, et al. The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis. Int J Mol Sci. 2021;22(5).
Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H. E., & Amer, S. (2021). The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 22(5). https://doi.org/10.3390/ijms22052734
Aboeldalyl S, et al. The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis. Int J Mol Sci. 2021 Mar 8;22(5) PubMed PMID: 33800490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis. AU - Aboeldalyl,Shaimaa, AU - James,Cathryn, AU - Seyam,Emaduldin, AU - Ibrahim,Emad Moussa, AU - Shawki,Hossam El-Din, AU - Amer,Saad, Y1 - 2021/03/08/ PY - 2021/02/18/received PY - 2021/03/03/revised PY - 2021/03/04/accepted PY - 2021/4/3/entrez PY - 2021/4/4/pubmed PY - 2021/4/23/medline KW - C-reactive protein KW - chronic inflammation KW - inflammatory markers KW - insulin resistance KW - obesity KW - polycystic ovarian syndrome JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 5 N2 - Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle-Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/33800490/The_Role_of_Chronic_Inflammation_in_Polycystic_Ovarian_Syndrome_A_Systematic_Review_and_Meta_Analysis_ DB - PRIME DP - Unbound Medicine ER -