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SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples.
Medicina (Kaunas). 2021 Mar 20; 57(3)M

Abstract

Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests' results on samples from the upper respiratory tract.

Authors+Show Affiliations

Department of Radiology, Moscati Hospital, Contrada Amoretta, 83100 Avellino, Italy.Specialist-Craniomed Laboratory Group srl, Viale degli Astronauti, 45, 83038 Montemiletto, Italy.European Commission, Joint Research Centre (JRC), Ispra, 21027 Via Enrico Fermi, Italy.Chief U.O. Emergency Unit-OBI P.O., Pineta Grande Hospital, Via Domitiana 3000, 81030 Castel Volturno, Italy.Chief Anatomy Pathology Department, Pineta Grande Hospital, Via Domitiana 3000, 81030 Castel Volturno, Italy.Specialist Andrology Unit, Service of Lifestyle Medicine in Uro-Andrology, Local Health Authority (ASL), 84121 Salerno, Italy.Department of Biology, University of Naples Federico II, 80138 Naples, Italy.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

33804646

Citation

Brogna, Barbara, et al. "SARS-CoV-2 Detection in Fecal Sample From a Patient With Typical Findings of COVID-19 Pneumonia On CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests On Oropharyngeal and Nasopharyngeal Swab Samples." Medicina (Kaunas, Lithuania), vol. 57, no. 3, 2021.
Brogna B, Brogna C, Petrillo M, et al. SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples. Medicina (Kaunas). 2021;57(3).
Brogna, B., Brogna, C., Petrillo, M., Conte, A. M., Benincasa, G., Montano, L., & Piscopo, M. (2021). SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples. Medicina (Kaunas, Lithuania), 57(3). https://doi.org/10.3390/medicina57030290
Brogna B, et al. SARS-CoV-2 Detection in Fecal Sample From a Patient With Typical Findings of COVID-19 Pneumonia On CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests On Oropharyngeal and Nasopharyngeal Swab Samples. Medicina (Kaunas). 2021 Mar 20;57(3) PubMed PMID: 33804646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples. AU - Brogna,Barbara, AU - Brogna,Carlo, AU - Petrillo,Mauro, AU - Conte,Adriana Modestina, AU - Benincasa,Giulio, AU - Montano,Luigi, AU - Piscopo,Marina, Y1 - 2021/03/20/ PY - 2021/02/08/received PY - 2021/03/15/revised PY - 2021/03/17/accepted PY - 2021/4/3/entrez PY - 2021/4/4/pubmed PY - 2021/4/13/medline KW - COVID-19 KW - RT-PCR KW - SARS-CoV-2 KW - chest KW - computed tomography KW - fecal swab KW - feces KW - nasopharyngeal swab KW - oropharyngeal swab KW - viral pneumonia JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 57 IS - 3 N2 - Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests' results on samples from the upper respiratory tract. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/33804646/SARS_CoV_2_Detection_in_Fecal_Sample_from_a_Patient_with_Typical_Findings_of_COVID_19_Pneumonia_on_CT_but_Negative_to_Multiple_SARS_CoV_2_RT_PCR_Tests_on_Oropharyngeal_and_Nasopharyngeal_Swab_Samples_ L2 - https://www.mdpi.com/resolver?pii=medicina57030290 DB - PRIME DP - Unbound Medicine ER -