TY - JOUR T1 - Examining the Impact of Squaric Acid as a Crosslinking Agent on the Properties of Chitosan-Based Films. AU - Olewnik-Kruszkowska,Ewa, AU - Gierszewska,Magdalena, AU - Grabska-Zielińska,Sylwia, AU - Skopińska-Wiśniewska,Joanna, AU - Jakubowska,Ewelina, Y1 - 2021/03/24/ PY - 2021/02/24/received PY - 2021/03/18/revised PY - 2021/03/20/accepted PY - 2021/4/3/entrez PY - 2021/4/4/pubmed PY - 2021/6/10/medline KW - chitosan KW - crosslinking KW - mechanical properties KW - squaric acid KW - swelling JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 7 N2 - Hydrogels based on chitosan are very versatile materials which can be used for tissue engineering as well as in controlled drug delivery systems. One of the methods for obtaining a chitosan-based hydrogel is crosslinking by applying different components. The objective of the present study was to obtain a series of new crosslinked chitosan-based films by means of solvent casting method. Squaric acid-3,4-dihydroxy-3-cyclobutene-1,2-dione-was used as a safe crosslinking agent. The effect of the squaric acid on the structural, mechanical, thermal, and swelling properties of the formed films was determined. It was established that the addition of the squaric acid significantly improved Young's modulus, tensile strength, and thermal stability of the obtained materials. Moreover, it should be stressed that the samples consisting of chitosan and squaric acid were characterized by a higher swelling than pure chitosan. The detailed characterization proved that squaric acid could be used as a new effective crosslinking agent. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/33805101/Examining_the_Impact_of_Squaric_Acid_as_a_Crosslinking_Agent_on_the_Properties_of_Chitosan_Based_Films_ DB - PRIME DP - Unbound Medicine ER -