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The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study.
J Prim Care Community Health. 2021 Jan-Dec; 12:21501327211005906.JP

Abstract

BACKGROUND

As the COVID-19 pandemic continues into flu season, it is critical to minimize hospitalizations to maximize capacity and preserve critical care resources. We sought to identify risk factors for influenza-related hospitalization, specifically the role of immunization and oseltamivir prescriptions.

METHODS

Patients with influenza diagnoses were identified from the MarketScan database (2014-2018). Primary risk factors of interest were an influenza vaccination within 6 months prior to infection and oseltamivir prescriptions (filled on the day diagnosis, the following day, or 2-5 days). A multivariable logistic regression model was run to identify risk factors for influenza-related hospitalizations within 30 days of diagnosis.

RESULTS

Among 2 395 498 influenza infections, 0.27% were hospitalized. Of those prescribed oseltamivir the day of diagnosis, 0.13% were later hospitalized, compared to 0.67% among those who filled prescriptions the following day and 11.8% when filled within 2 to 5 days. Upon adjustment, oseltamivir prescriptions filled on the day of diagnosis were associated with significantly decreased odds of hospitalization (OR 0.51 CI 0.48-0.55). Prescriptions filled within 1 to 5 days of diagnosis were associated with significantly increased odds of hospitalization (1 day OR 2.01 CI 1.81-2.24; 2-5 days OR 34.1 CI 31.7-36.6). Flu vaccination was associated with a lower odds for hospitalization (OR 0.84 CI 0.74-0.95).

CONCLUSIONS

We recommend oseltamivir be prescribed to patients when they first present with influenza-like symptoms to reduce the burden on the healthcare system. We also identified reduced odds of hospitalization associated with influenza vaccination, which is already well established, but particularly important this coming flu season.

Authors+Show Affiliations

Oxford University Hospitals NHS Foundation Trust, Oxford, UK.Hospital for Special Surgery, New York, NY, USA.Hospital for Special Surgery, New York, NY, USA. Weill Cornell Medicine, New York, NY, USA.Icahn School of Medicine at Mount Sinai, New York, NY, USA.Hospital for Special Surgery, New York, NY, USA.Hospital for Special Surgery, New York, NY, USA. Weill Cornell Medicine, New York, NY, USA. Weill Cornell Medical College, New York, NY, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33829910

Citation

Athanassoglou, Vassilis, et al. "The Impact of Immunization and Use of Oseltamivir On Influenza-Related Hospitalizations: a Population-Based Study." Journal of Primary Care & Community Health, vol. 12, 2021, p. 21501327211005906.
Athanassoglou V, Wilson LA, Liu J, et al. The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study. J Prim Care Community Health. 2021;12:21501327211005906.
Athanassoglou, V., Wilson, L. A., Liu, J., Poeran, J., Zhong, H., & Memtsoudis, S. G. (2021). The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study. Journal of Primary Care & Community Health, 12, 21501327211005906. https://doi.org/10.1177/21501327211005906
Athanassoglou V, et al. The Impact of Immunization and Use of Oseltamivir On Influenza-Related Hospitalizations: a Population-Based Study. J Prim Care Community Health. 2021 Jan-Dec;12:21501327211005906. PubMed PMID: 33829910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study. AU - Athanassoglou,Vassilis, AU - Wilson,Lauren A, AU - Liu,Jiabin, AU - Poeran,Jashvant, AU - Zhong,Haoyan, AU - Memtsoudis,Stavros G, PY - 2021/4/8/entrez PY - 2021/4/9/pubmed PY - 2021/5/6/medline KW - Tamiflu KW - hospitalization KW - immunization KW - influenza KW - oseltamivir SP - 21501327211005906 EP - 21501327211005906 JF - Journal of primary care & community health JO - J Prim Care Community Health VL - 12 N2 - BACKGROUND: As the COVID-19 pandemic continues into flu season, it is critical to minimize hospitalizations to maximize capacity and preserve critical care resources. We sought to identify risk factors for influenza-related hospitalization, specifically the role of immunization and oseltamivir prescriptions. METHODS: Patients with influenza diagnoses were identified from the MarketScan database (2014-2018). Primary risk factors of interest were an influenza vaccination within 6 months prior to infection and oseltamivir prescriptions (filled on the day diagnosis, the following day, or 2-5 days). A multivariable logistic regression model was run to identify risk factors for influenza-related hospitalizations within 30 days of diagnosis. RESULTS: Among 2 395 498 influenza infections, 0.27% were hospitalized. Of those prescribed oseltamivir the day of diagnosis, 0.13% were later hospitalized, compared to 0.67% among those who filled prescriptions the following day and 11.8% when filled within 2 to 5 days. Upon adjustment, oseltamivir prescriptions filled on the day of diagnosis were associated with significantly decreased odds of hospitalization (OR 0.51 CI 0.48-0.55). Prescriptions filled within 1 to 5 days of diagnosis were associated with significantly increased odds of hospitalization (1 day OR 2.01 CI 1.81-2.24; 2-5 days OR 34.1 CI 31.7-36.6). Flu vaccination was associated with a lower odds for hospitalization (OR 0.84 CI 0.74-0.95). CONCLUSIONS: We recommend oseltamivir be prescribed to patients when they first present with influenza-like symptoms to reduce the burden on the healthcare system. We also identified reduced odds of hospitalization associated with influenza vaccination, which is already well established, but particularly important this coming flu season. SN - 2150-1327 UR - https://www.unboundmedicine.com/medline/citation/33829910/The_Impact_of_Immunization_and_Use_of_Oseltamivir_on_Influenza-Related_Hospitalizations:_A_Population-Based_Study. L2 - https://journals.sagepub.com/doi/10.1177/21501327211005906?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -