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Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway.
Mol Psychiatry. 2022 01; 27(1):230-248.MP

Abstract

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear. Recent findings have shown that oxidative stress, inflammation, and glutamatergic pathways play key roles in the causes of OCD. However, first-line therapies include cognitive-behavioral therapy but only 40% of the patients respond to this first-line therapy. Research for new treatment is mandatory. This review focuses on the potential effects of cannabidiol (CBD), as a potential therapeutic strategy, on OCD and some of the presumed mechanisms by which CBD provides its benefit properties. CBD medication downregulates GSK-3β, the main inhibitor of the WNT/β-catenin pathway. The activation of the WNT/β-catenin could be associated with the control of oxidative stress, inflammation, and glutamatergic pathway and circadian rhythms dysregulation in OCD. Future prospective clinical trials could focus on CBD and its different and multiple interactions in OCD.

Authors+Show Affiliations

Department of Clinical Research and Innovation (DRCI), Foch Hospital, Suresnes, France. alexandre.g.vallee@mail.com.Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), Meaux, France.Centre Hospitalier Universitaire (CHU) Amiens Picardie, Université Picardie Jules Verne (UPJV), Amiens, France. Laboratoire de Mathématiques et Applications (LMA), UMR CNRS 7348, Université de Poitiers, Poitiers, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33837269

Citation

Vallée, Alexandre, et al. "Possible Actions of Cannabidiol in Obsessive-compulsive Disorder By Targeting the WNT/β-catenin Pathway." Molecular Psychiatry, vol. 27, no. 1, 2022, pp. 230-248.
Vallée A, Lecarpentier Y, Vallée JN. Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway. Mol Psychiatry. 2022;27(1):230-248.
Vallée, A., Lecarpentier, Y., & Vallée, J. N. (2022). Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway. Molecular Psychiatry, 27(1), 230-248. https://doi.org/10.1038/s41380-021-01086-1
Vallée A, Lecarpentier Y, Vallée JN. Possible Actions of Cannabidiol in Obsessive-compulsive Disorder By Targeting the WNT/β-catenin Pathway. Mol Psychiatry. 2022;27(1):230-248. PubMed PMID: 33837269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway. AU - Vallée,Alexandre, AU - Lecarpentier,Yves, AU - Vallée,Jean-Noël, Y1 - 2021/04/09/ PY - 2021/01/08/received PY - 2021/03/26/accepted PY - 2021/03/13/revised PY - 2021/4/11/pubmed PY - 2022/5/3/medline PY - 2021/4/10/entrez SP - 230 EP - 248 JF - Molecular psychiatry JO - Mol Psychiatry VL - 27 IS - 1 N2 - Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent and distinctive obsessions and/or compulsions. The etiologies remain unclear. Recent findings have shown that oxidative stress, inflammation, and glutamatergic pathways play key roles in the causes of OCD. However, first-line therapies include cognitive-behavioral therapy but only 40% of the patients respond to this first-line therapy. Research for new treatment is mandatory. This review focuses on the potential effects of cannabidiol (CBD), as a potential therapeutic strategy, on OCD and some of the presumed mechanisms by which CBD provides its benefit properties. CBD medication downregulates GSK-3β, the main inhibitor of the WNT/β-catenin pathway. The activation of the WNT/β-catenin could be associated with the control of oxidative stress, inflammation, and glutamatergic pathway and circadian rhythms dysregulation in OCD. Future prospective clinical trials could focus on CBD and its different and multiple interactions in OCD. SN - 1476-5578 UR - https://www.unboundmedicine.com/medline/citation/33837269/Possible_actions_of_cannabidiol_in_obsessive_compulsive_disorder_by_targeting_the_WNT/β_catenin_pathway_ L2 - https://doi.org/10.1038/s41380-021-01086-1 DB - PRIME DP - Unbound Medicine ER -