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Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia.
Endoscopy. 1988 Mar; 20(2):52-6.E

Abstract

Among 196 patients examined in 1972-1985 because of pernicious anemia (PA), 105 patients under the age of 76 years were invited for gastroscopic screening, and 71 patients (68%) participated. Gastroscopy revealed carcinoid tumor(s) in 5 patients (7%) but no case of carcinoma. In addition, one patient with gastric carcinoid, 5 patients with adenocarcinomas and one with a concomitant carcinoid and carcinoma had already been diagnosed earlier in the overall PA group on the basis of clinical symptoms. Thus, within a follow-up of 0-20 years (mean 7 years) the total frequency of gastric carcinoid tumors was 4% and that of carcinoma 3%. Patients with carcinoid tumors had a long duration of PA and young age of onset; these cases were not necessarily those with the highest serum gastrin levels. Even though most gastric carcinoids are small subclinical tumors of uncertain clinical significance, their unexpectedly high frequency, combined within the risk of carcinoma in PA, might indicate the need for gastroscopic follow-up, at least in cases of juvenile onset PA.

Authors+Show Affiliations

Second Department of Surgery, University Central Hospital, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3383791

Citation

Sjöblom, S M., et al. "Gastroscopic Screening for Gastric Carcinoids and Carcinoma in Pernicious Anemia." Endoscopy, vol. 20, no. 2, 1988, pp. 52-6.
Sjöblom SM, Sipponen P, Miettinen M, et al. Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia. Endoscopy. 1988;20(2):52-6.
Sjöblom, S. M., Sipponen, P., Miettinen, M., Karonen, S. L., & Jrvinen, H. J. (1988). Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia. Endoscopy, 20(2), 52-6.
Sjöblom SM, et al. Gastroscopic Screening for Gastric Carcinoids and Carcinoma in Pernicious Anemia. Endoscopy. 1988;20(2):52-6. PubMed PMID: 3383791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroscopic screening for gastric carcinoids and carcinoma in pernicious anemia. AU - Sjöblom,S M, AU - Sipponen,P, AU - Miettinen,M, AU - Karonen,S L, AU - Jrvinen,H J, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 52 EP - 6 JF - Endoscopy JO - Endoscopy VL - 20 IS - 2 N2 - Among 196 patients examined in 1972-1985 because of pernicious anemia (PA), 105 patients under the age of 76 years were invited for gastroscopic screening, and 71 patients (68%) participated. Gastroscopy revealed carcinoid tumor(s) in 5 patients (7%) but no case of carcinoma. In addition, one patient with gastric carcinoid, 5 patients with adenocarcinomas and one with a concomitant carcinoid and carcinoma had already been diagnosed earlier in the overall PA group on the basis of clinical symptoms. Thus, within a follow-up of 0-20 years (mean 7 years) the total frequency of gastric carcinoid tumors was 4% and that of carcinoma 3%. Patients with carcinoid tumors had a long duration of PA and young age of onset; these cases were not necessarily those with the highest serum gastrin levels. Even though most gastric carcinoids are small subclinical tumors of uncertain clinical significance, their unexpectedly high frequency, combined within the risk of carcinoma in PA, might indicate the need for gastroscopic follow-up, at least in cases of juvenile onset PA. SN - 0013-726X UR - https://www.unboundmedicine.com/medline/citation/3383791/Gastroscopic_screening_for_gastric_carcinoids_and_carcinoma_in_pernicious_anemia_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1018130 DB - PRIME DP - Unbound Medicine ER -