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Antibacterial efficacy of quaternized chitosan/poly (vinyl alcohol) nanofiber membrane crosslinked with blocked diisocyanate.
Carbohydr Polym. 2021 Jun 15; 262:117910.CP

Abstract

N-[(2-hydroxyl-3-trimethylammonium) propyl] chitosan chloride (HTCC), which is a type of chitosan derivative with quaternary ammonium groups, possesses a higher antibacterial activity as compared to the pristine chitosan. The nanofiber membranes made of HTCC are attractive for applications demanding for antibacterial function. However, the hydrophilic nature of HTCC makes it unsuitable for electrospinning of nanofibers. Hence, biodegradable polyvinyl alcohol (PVA) was proposed as an additive to improve the electrospinnability of HTCC. In this work, PVA/HTCC nanofiber membrane was crosslinked with the blocked diisocyanate (BI) to enhance the stability of nanofiber membrane in water. Microbiological assessments showed that the PVA/HTCC/BI nanofiber membranes possessed a good antibacterial efficacy (∼100 %) against E. coli. Moreover, the biocompatibility of PVA/HTCC/BI nanofiber membrane was proven by the cytotoxicity test on mouse fibroblasts. These promising results indicated that the PVA/HTCC/BI nanofiber membrane can be a promising material for food packaging and as a potential wound dressing for skin regeneration.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wu JY
Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan.
Ooi CW
Chemical Engineering Discipline and Advanced Engineering Platform, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
Song CP
Chemical Engineering Discipline and Advanced Engineering Platform, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
Wang CY
International Ph. D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, 243303, Taiwan.
Liu BL
Department of Applied Chemistry, Chaoyang University of Technology, Taichung, 413310, Taiwan.
Lin GY
Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan.
Chiu CY
Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan.
Chang YK
Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan. Electronic address: ykchang@mail.mcut.edu.tw.

MeSH

AnimalsAnti-Bacterial AgentsBandagesCell LineChitosanCross-Linking ReagentsEscherichia coliFood PackagingHydrophobic and Hydrophilic InteractionsIsocyanatesMiceNanofibersPolyvinyl AlcoholQuaternary Ammonium Compounds

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33838797

Citation

Wu, Jheng-Yu, et al. "Antibacterial Efficacy of Quaternized Chitosan/poly (vinyl Alcohol) Nanofiber Membrane Crosslinked With Blocked Diisocyanate." Carbohydrate Polymers, vol. 262, 2021, p. 117910.
Wu JY, Ooi CW, Song CP, et al. Antibacterial efficacy of quaternized chitosan/poly (vinyl alcohol) nanofiber membrane crosslinked with blocked diisocyanate. Carbohydr Polym. 2021;262:117910.
Wu, J. Y., Ooi, C. W., Song, C. P., Wang, C. Y., Liu, B. L., Lin, G. Y., Chiu, C. Y., & Chang, Y. K. (2021). Antibacterial efficacy of quaternized chitosan/poly (vinyl alcohol) nanofiber membrane crosslinked with blocked diisocyanate. Carbohydrate Polymers, 262, 117910. https://doi.org/10.1016/j.carbpol.2021.117910
Wu JY, et al. Antibacterial Efficacy of Quaternized Chitosan/poly (vinyl Alcohol) Nanofiber Membrane Crosslinked With Blocked Diisocyanate. Carbohydr Polym. 2021 Jun 15;262:117910. PubMed PMID: 33838797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial efficacy of quaternized chitosan/poly (vinyl alcohol) nanofiber membrane crosslinked with blocked diisocyanate. AU - Wu,Jheng-Yu, AU - Ooi,Chien Wei, AU - Song,Cher Pin, AU - Wang,Chi-Yun, AU - Liu,Bing-Lan, AU - Lin,Guan-Yu, AU - Chiu,Chen-Yaw, AU - Chang,Yu-Kaung, Y1 - 2021/03/05/ PY - 2020/07/10/received PY - 2021/01/26/revised PY - 2021/03/02/accepted PY - 2021/4/11/entrez PY - 2021/4/12/pubmed PY - 2021/9/4/medline KW - Antibacterial KW - Blocked diisocyanate KW - Chitosan KW - E. coli KW - Nanofiber membrane KW - Polyvinyl alcohol SP - 117910 EP - 117910 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 262 N2 - N-[(2-hydroxyl-3-trimethylammonium) propyl] chitosan chloride (HTCC), which is a type of chitosan derivative with quaternary ammonium groups, possesses a higher antibacterial activity as compared to the pristine chitosan. The nanofiber membranes made of HTCC are attractive for applications demanding for antibacterial function. However, the hydrophilic nature of HTCC makes it unsuitable for electrospinning of nanofibers. Hence, biodegradable polyvinyl alcohol (PVA) was proposed as an additive to improve the electrospinnability of HTCC. In this work, PVA/HTCC nanofiber membrane was crosslinked with the blocked diisocyanate (BI) to enhance the stability of nanofiber membrane in water. Microbiological assessments showed that the PVA/HTCC/BI nanofiber membranes possessed a good antibacterial efficacy (∼100 %) against E. coli. Moreover, the biocompatibility of PVA/HTCC/BI nanofiber membrane was proven by the cytotoxicity test on mouse fibroblasts. These promising results indicated that the PVA/HTCC/BI nanofiber membrane can be a promising material for food packaging and as a potential wound dressing for skin regeneration. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/33838797/Antibacterial_efficacy_of_quaternized_chitosan/poly__vinyl_alcohol__nanofiber_membrane_crosslinked_with_blocked_diisocyanate_ DB - PRIME DP - Unbound Medicine ER -