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Immunoglobulins in the jejunal mucosa in adult coeliac disease and dermatitis herpetiformis after the reintroduction of dietary gluten.
Gut. 1977 Nov; 18(11):887-91.Gut

Abstract

Cells containing immunoglobulin (IgA, IgG, IgM) have been measured and the distribution of extracellular and epithelial cell immunoglobulin assessed in treated patients with adult coeliac disease (ACD) and dermatitis herpetiformis (DH) before and after gluten was reintroduced to the diet. Patients with ACD and DH frequently had IgM and IgG cells above the normal range even before re-exposure to gluten, although the range of IgA cells was normal. In both diseases IgA and IgM cells increased after gluten with a proportionally greater rise in the latter, so that numbers of IgM cells, but not of IgA, exceeded the control range in all but one patient. There were increased quantities of IgA and IgM extracellularly in the lamina propria and in epithelial cells after challenge with gluten. Third component of complement was also found in some biopsies after re-exposure to gluten. These findings support the suggestion that gluten induces a humoral immunological response within the small intestinal mucosa and that both IgA and IgM systems are involved.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

338443

Citation

Lancaster-Smith, M, et al. "Immunoglobulins in the Jejunal Mucosa in Adult Coeliac Disease and Dermatitis Herpetiformis After the Reintroduction of Dietary Gluten." Gut, vol. 18, no. 11, 1977, pp. 887-91.
Lancaster-Smith M, Joyce S, Kumar P. Immunoglobulins in the jejunal mucosa in adult coeliac disease and dermatitis herpetiformis after the reintroduction of dietary gluten. Gut. 1977;18(11):887-91.
Lancaster-Smith, M., Joyce, S., & Kumar, P. (1977). Immunoglobulins in the jejunal mucosa in adult coeliac disease and dermatitis herpetiformis after the reintroduction of dietary gluten. Gut, 18(11), 887-91.
Lancaster-Smith M, Joyce S, Kumar P. Immunoglobulins in the Jejunal Mucosa in Adult Coeliac Disease and Dermatitis Herpetiformis After the Reintroduction of Dietary Gluten. Gut. 1977;18(11):887-91. PubMed PMID: 338443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulins in the jejunal mucosa in adult coeliac disease and dermatitis herpetiformis after the reintroduction of dietary gluten. AU - Lancaster-Smith,M, AU - Joyce,S, AU - Kumar,P, PY - 1977/11/1/pubmed PY - 1977/11/1/medline PY - 1977/11/1/entrez SP - 887 EP - 91 JF - Gut JO - Gut VL - 18 IS - 11 N2 - Cells containing immunoglobulin (IgA, IgG, IgM) have been measured and the distribution of extracellular and epithelial cell immunoglobulin assessed in treated patients with adult coeliac disease (ACD) and dermatitis herpetiformis (DH) before and after gluten was reintroduced to the diet. Patients with ACD and DH frequently had IgM and IgG cells above the normal range even before re-exposure to gluten, although the range of IgA cells was normal. In both diseases IgA and IgM cells increased after gluten with a proportionally greater rise in the latter, so that numbers of IgM cells, but not of IgA, exceeded the control range in all but one patient. There were increased quantities of IgA and IgM extracellularly in the lamina propria and in epithelial cells after challenge with gluten. Third component of complement was also found in some biopsies after re-exposure to gluten. These findings support the suggestion that gluten induces a humoral immunological response within the small intestinal mucosa and that both IgA and IgM systems are involved. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/338443/Immunoglobulins_in_the_jejunal_mucosa_in_adult_coeliac_disease_and_dermatitis_herpetiformis_after_the_reintroduction_of_dietary_gluten_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=338443 DB - PRIME DP - Unbound Medicine ER -