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Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus).
BMC Vet Res. 2021 Apr 12; 17(1):154.BV

Abstract

BACKGROUND

Acute kidney injury (AKI) is associated with high morbidity and mortality in dogs, but diagnosis may be impaired due the insensitivity of routine renal function biomarkers to detect earlier or milder forms of injury. Snake envenomation is one of several causes of AKI in dogs and humans. Dogs are commonly envenomated by the European adder (Vipera berus) between April and October each year, but few studies exist examining serial serum creatinine (sCr) and symmetric dimethylarginine (SDMA) measurements and AKI biomarkers in these dogs. Novel urinary biomarkers could improve clinical outcome by allowing earlier diagnosis of and intervention in AKI. The aim of this study was to assess the presence of AKI in dogs envenomated by V. berus at 12, 24 and 36 h after bite, as well as 14 days later, using sCr, SDMA and a panel of urinary AKI biomarkers normalised to urine creatinine (uCr), compared to a group of healthy control dogs.

RESULTS

Thirty-five envenomated dogs and 35 control dogs were included. Serum creatinine did not exceed the upper reference limit at any time point in any dog after envenomation. Serum SDMA did not exceed 0.89 μmol/L in any dog. Compared to controls, urinary albumin/uCr, neutrophil gelatinase-associated lipocalin/uCr and monocyte chemotactic protein-1/uCr were significantly elevated 12 h (P < 0.0001, P < 0.0001, P = 0.01), 24 h (P < 0.001, P < 0.001, P = 0.002) and 36 h (P < 0.001, P < 0.001, P = 0.0008) after bite. Osteopontin/uCr was higher 24 and 36 h after bite (P < 0.0001), kidney injury molecule-1/uCr, interleukin-8/uCr and γ- glutamyl transferase/uCr were significantly higher 36 h after bite (P = 0.003, P = 0.0005, P = 0.001). Urinary cystatin C/uCr was not significantly different to controls at any timepoint. Biomarker/uCr ratios were not significantly different 14 days after envenomation compared to controls.

CONCLUSION

Urinary biomarker/Cr ratios are indicative of mild transient, non-azotaemic AKI in dogs envenomated by V. berus.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Oslo, Norway. Hannah.harjen@nmbu.no.Faculty of Veterinary Medicine, Department of Preclinical sciences and Pathology, Norwegian University of Life Sciences, Oslo, Norway.Anicura Jeløy Dyresykehus, Moss, Norway.Faculty of Veterinary Medicine, Department of Preclinical sciences and Pathology, Norwegian University of Life Sciences, Oslo, Norway.Anicura Jeløy Dyresykehus, Moss, Norway.Faculty of Veterinary Medicine, Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Oslo, Norway.Faculty of Veterinary Medicine, Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Oslo, Norway.Faculty of Veterinary Medicine, Department of Preclinical sciences and Pathology, Norwegian University of Life Sciences, Oslo, Norway.Faculty of Veterinary Medicine, Department of Preclinical sciences and Pathology, Norwegian University of Life Sciences, Oslo, Norway.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33845861

Citation

Harjen, Hannah J., et al. "Serial Serum Creatinine, SDMA and Urinary Acute Kidney Injury Biomarker Measurements in Dogs Envenomated By the European Adder (Vipera Berus)." BMC Veterinary Research, vol. 17, no. 1, 2021, p. 154.
Harjen HJ, Nicolaysen TV, Negard T, et al. Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus). BMC Vet Res. 2021;17(1):154.
Harjen, H. J., Nicolaysen, T. V., Negard, T., Lund, H., Sævik, B. K., Anfinsen, K. P., Moldal, E. R., Zimmer, K. E., & Rørtveit, R. (2021). Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus). BMC Veterinary Research, 17(1), 154. https://doi.org/10.1186/s12917-021-02851-8
Harjen HJ, et al. Serial Serum Creatinine, SDMA and Urinary Acute Kidney Injury Biomarker Measurements in Dogs Envenomated By the European Adder (Vipera Berus). BMC Vet Res. 2021 Apr 12;17(1):154. PubMed PMID: 33845861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus). AU - Harjen,Hannah J, AU - Nicolaysen,Tove V, AU - Negard,Tale, AU - Lund,Hege, AU - Sævik,Bente K, AU - Anfinsen,Kristin P, AU - Moldal,Elena R, AU - Zimmer,Karin E, AU - Rørtveit,Runa, Y1 - 2021/04/12/ PY - 2020/12/17/received PY - 2021/03/25/accepted PY - 2021/4/13/entrez PY - 2021/4/14/pubmed PY - 2021/8/26/medline KW - Acute kidney injury KW - Adder KW - Biomarker KW - Renal KW - Snakebite KW - Viper SP - 154 EP - 154 JF - BMC veterinary research JO - BMC Vet Res VL - 17 IS - 1 N2 - BACKGROUND: Acute kidney injury (AKI) is associated with high morbidity and mortality in dogs, but diagnosis may be impaired due the insensitivity of routine renal function biomarkers to detect earlier or milder forms of injury. Snake envenomation is one of several causes of AKI in dogs and humans. Dogs are commonly envenomated by the European adder (Vipera berus) between April and October each year, but few studies exist examining serial serum creatinine (sCr) and symmetric dimethylarginine (SDMA) measurements and AKI biomarkers in these dogs. Novel urinary biomarkers could improve clinical outcome by allowing earlier diagnosis of and intervention in AKI. The aim of this study was to assess the presence of AKI in dogs envenomated by V. berus at 12, 24 and 36 h after bite, as well as 14 days later, using sCr, SDMA and a panel of urinary AKI biomarkers normalised to urine creatinine (uCr), compared to a group of healthy control dogs. RESULTS: Thirty-five envenomated dogs and 35 control dogs were included. Serum creatinine did not exceed the upper reference limit at any time point in any dog after envenomation. Serum SDMA did not exceed 0.89 μmol/L in any dog. Compared to controls, urinary albumin/uCr, neutrophil gelatinase-associated lipocalin/uCr and monocyte chemotactic protein-1/uCr were significantly elevated 12 h (P < 0.0001, P < 0.0001, P = 0.01), 24 h (P < 0.001, P < 0.001, P = 0.002) and 36 h (P < 0.001, P < 0.001, P = 0.0008) after bite. Osteopontin/uCr was higher 24 and 36 h after bite (P < 0.0001), kidney injury molecule-1/uCr, interleukin-8/uCr and γ- glutamyl transferase/uCr were significantly higher 36 h after bite (P = 0.003, P = 0.0005, P = 0.001). Urinary cystatin C/uCr was not significantly different to controls at any timepoint. Biomarker/uCr ratios were not significantly different 14 days after envenomation compared to controls. CONCLUSION: Urinary biomarker/Cr ratios are indicative of mild transient, non-azotaemic AKI in dogs envenomated by V. berus. SN - 1746-6148 UR - https://www.unboundmedicine.com/medline/citation/33845861/Serial_serum_creatinine_SDMA_and_urinary_acute_kidney_injury_biomarker_measurements_in_dogs_envenomated_by_the_European_adder__Vipera_berus__ DB - PRIME DP - Unbound Medicine ER -