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Potential role of cannabidiol in Parkinson's disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation.
Aging (Albany NY). 2021 04 13; 13(7):10796-10813.A

Abstract

Parkinson's disease (PD) is a major neurodegenerative disease (ND), presenting a progressive degeneration of the nervous system characterized by a loss of dopamine in the substantia nigra pars compacta. Recent findings have shown that oxidative stress and inflammation play key roles in the development of PD. However, therapies remain uncertain and research for new treatment is of the utmost importance. This review focuses on the potential effects of using cannabidiol (CBD) as a potential therapeutic strategy for the treatment of PD and on some of the presumed mechanisms by which CBD provides its beneficial properties. CBD medication downregulates GSK-3β, the main inhibitor of the WNT/β-catenin pathway. Activation of the WNT/β-catenin could be associated with the control of oxidative stress and inflammation. Future prospective clinical trials should focus on CBD and its multiple interactions in the treatment of PD.

Authors+Show Affiliations

Department of Clinical Research and Innovation (DRCI), Foch Hospital, Suresnes 92150, France.Centre Hospitalier Universitaire (CHU) Amiens Picardie, Université Picardie Jules Verne (UPJV), Amiens 80054, France. Laboratoire de Mathématiques et Applications (LMA), UMR CNRS 7348, Université de Poitiers, Poitiers 86000, France.Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), Meaux 77100, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33848261

Citation

Vallée, Alexandre, et al. "Potential Role of Cannabidiol in Parkinson's Disease By Targeting the WNT/β-catenin Pathway, Oxidative Stress and Inflammation." Aging, vol. 13, no. 7, 2021, pp. 10796-10813.
Vallée A, Vallée JN, Lecarpentier Y. Potential role of cannabidiol in Parkinson's disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation. Aging (Albany NY). 2021;13(7):10796-10813.
Vallée, A., Vallée, J. N., & Lecarpentier, Y. (2021). Potential role of cannabidiol in Parkinson's disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation. Aging, 13(7), 10796-10813. https://doi.org/10.18632/aging.202951
Vallée A, Vallée JN, Lecarpentier Y. Potential Role of Cannabidiol in Parkinson's Disease By Targeting the WNT/β-catenin Pathway, Oxidative Stress and Inflammation. Aging (Albany NY). 2021 04 13;13(7):10796-10813. PubMed PMID: 33848261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential role of cannabidiol in Parkinson's disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation. AU - Vallée,Alexandre, AU - Vallée,Jean-Noël, AU - Lecarpentier,Yves, Y1 - 2021/04/13/ PY - 2020/11/20/received PY - 2021/03/26/accepted PY - 2021/4/14/pubmed PY - 2021/8/17/medline PY - 2021/4/13/entrez KW - Parkinson's disease KW - WNT/β-catenin pathway KW - cannabidiol KW - inflammation KW - oxidative stress SP - 10796 EP - 10813 JF - Aging JO - Aging (Albany NY) VL - 13 IS - 7 N2 - Parkinson's disease (PD) is a major neurodegenerative disease (ND), presenting a progressive degeneration of the nervous system characterized by a loss of dopamine in the substantia nigra pars compacta. Recent findings have shown that oxidative stress and inflammation play key roles in the development of PD. However, therapies remain uncertain and research for new treatment is of the utmost importance. This review focuses on the potential effects of using cannabidiol (CBD) as a potential therapeutic strategy for the treatment of PD and on some of the presumed mechanisms by which CBD provides its beneficial properties. CBD medication downregulates GSK-3β, the main inhibitor of the WNT/β-catenin pathway. Activation of the WNT/β-catenin could be associated with the control of oxidative stress and inflammation. Future prospective clinical trials should focus on CBD and its multiple interactions in the treatment of PD. SN - 1945-4589 UR - https://www.unboundmedicine.com/medline/citation/33848261/Potential_role_of_cannabidiol_in_Parkinson's_disease_by_targeting_the_WNT/��_catenin_pathway_oxidative_stress_and_inflammation_ L2 - https://www.impactaging.com/full/13/10796 DB - PRIME DP - Unbound Medicine ER -