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Gastroduodenal endoscopic-histologic correlation in pediatric patients.
J Pediatr Gastroenterol Nutr. 1988 May-Jun; 7(3):353-8.JP

Abstract

The histopathologic abnormalities in endoscopic biopsies from the stomach and duodenal bulb were correlated with the visual findings of upper gastrointestinal endoscopy in 94 children (mean age, 8.4 years; 51 boys and 43 girls) with a variety of complaints. Histology was graded by observers blinded to the endoscopic findings, and both endoscopy and histology were graded using scales reflecting increasing severity with increasing grade. In all three locations studied (gastric body, antrum, and duodenal bulb), endoscopic grade was significantly higher than the histologic grade. Correlation was especially poor with mild endoscopic findings such as erythema and granularity/nodularity, which had little predictive value for histologic inflammation. Few patients had severe disease with eight of 94 having ulcer by endoscopy and seven of 94 having greater than grade 2 histologic disease in any location. We conclude that endoscopy without biopsy should not be used to diagnose gastroduodenal inflammation in pediatric patients.

Authors+Show Affiliations

Department of Pediatrics, University of Tennessee Center for the Health Sciences, Memphis.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3385547

Citation

Black, D D., et al. "Gastroduodenal Endoscopic-histologic Correlation in Pediatric Patients." Journal of Pediatric Gastroenterology and Nutrition, vol. 7, no. 3, 1988, pp. 353-8.
Black DD, Haggitt RC, Whitington PF. Gastroduodenal endoscopic-histologic correlation in pediatric patients. J Pediatr Gastroenterol Nutr. 1988;7(3):353-8.
Black, D. D., Haggitt, R. C., & Whitington, P. F. (1988). Gastroduodenal endoscopic-histologic correlation in pediatric patients. Journal of Pediatric Gastroenterology and Nutrition, 7(3), 353-8.
Black DD, Haggitt RC, Whitington PF. Gastroduodenal Endoscopic-histologic Correlation in Pediatric Patients. J Pediatr Gastroenterol Nutr. 1988 May-Jun;7(3):353-8. PubMed PMID: 3385547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroduodenal endoscopic-histologic correlation in pediatric patients. AU - Black,D D, AU - Haggitt,R C, AU - Whitington,P F, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 353 EP - 8 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 7 IS - 3 N2 - The histopathologic abnormalities in endoscopic biopsies from the stomach and duodenal bulb were correlated with the visual findings of upper gastrointestinal endoscopy in 94 children (mean age, 8.4 years; 51 boys and 43 girls) with a variety of complaints. Histology was graded by observers blinded to the endoscopic findings, and both endoscopy and histology were graded using scales reflecting increasing severity with increasing grade. In all three locations studied (gastric body, antrum, and duodenal bulb), endoscopic grade was significantly higher than the histologic grade. Correlation was especially poor with mild endoscopic findings such as erythema and granularity/nodularity, which had little predictive value for histologic inflammation. Few patients had severe disease with eight of 94 having ulcer by endoscopy and seven of 94 having greater than grade 2 histologic disease in any location. We conclude that endoscopy without biopsy should not be used to diagnose gastroduodenal inflammation in pediatric patients. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/3385547/Gastroduodenal_endoscopic_histologic_correlation_in_pediatric_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3385547.ui DB - PRIME DP - Unbound Medicine ER -