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Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19.
Life Sci. 2021 Aug 01; 278:119510.LS

Abstract

Currently, the world has been devastated by an unprecedented pandemic in this century. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the agent of coronavirus disease 2019 (COVID-19), has been causing disorders, dysfunction and morphophysiological alterations in multiple organs as the disease evolves. There is a great scientific community effort to obtain a therapy capable of reaching the multiple affected organs in order to contribute for tissue repair and regeneration. In this regard, mesenchymal stem cells (MSCs) have emerged as potential candidates concerning the promotion of beneficial actions at different stages of COVID-19. MSCs are promising due to the observed therapeutic effects in respiratory preclinical models, as well as in cardiac, vascular, renal and nervous system models. Their immunomodulatory properties and secretion of paracrine mediators, such as cytokines, chemokines, growth factors and extracellular vesicles allow for long range tissue modulation and, particularly, blood-brain barrier crossing. This review focuses on SARS-CoV-2 impact to lungs, kidneys, heart, vasculature and central nervous system while discussing promising MSC's therapeutic mechanisms in each tissue. In addition, MSC's therapeutic effects in high-risk groups for COVID-19, such as obese, diabetic and hypertensive patients are also explored.

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Authors+Show Affiliations

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

LPCT - Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: alethole@gmail.com.

MeSH

AnimalsCOVID-19HumansImmunomodulationMesenchymal Stem Cell TransplantationMesenchymal Stem CellsSARS-CoV-2

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

33865879

Citation

Paris, Gustavo C., et al. "Therapeutic Potential of Mesenchymal Stem Cells in Multiple Organs Affected By COVID-19." Life Sciences, vol. 278, 2021, p. 119510.

Paris GC, Azevedo AA, Ferreira AL, et al. Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19. Life Sci. 2021;278:119510.

Paris, G. C., Azevedo, A. A., Ferreira, A. L., Azevedo, Y. M. A., Rainho, M. A., Oliveira, G. P., Silva, K. R., Cortez, E. A. C., Stumbo, A. C., Carvalho, S. N., de Carvalho, L., & Thole, A. A. (2021). Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19. Life Sciences, 278, 119510. https://doi.org/10.1016/j.lfs.2021.119510

Paris GC, et al. Therapeutic Potential of Mesenchymal Stem Cells in Multiple Organs Affected By COVID-19. Life Sci. 2021 Aug 1;278:119510. PubMed PMID: 33865879.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Therapeutic potential of mesenchymal stem cells in multiple organs affected by COVID-19. AU - Paris,Gustavo C, AU - Azevedo,Aline A, AU - Ferreira,Adriana L, AU - Azevedo,Yanca M A, AU - Rainho,Mateus A, AU - Oliveira,Genilza P, AU - Silva,Karina R, AU - Cortez,Erika A C, AU - Stumbo,Ana C, AU - Carvalho,Simone N, AU - de Carvalho,Lais, AU - Thole,Alessandra A, Y1 - 2021/04/15/ PY - 2021/03/03/received PY - 2021/04/05/revised PY - 2021/04/06/accepted PY - 2021/4/19/pubmed PY - 2021/6/22/medline PY - 2021/4/18/entrez KW - Cell therapy KW - Cytokine storm KW - Immunomodulation KW - MSC KW - SARS-CoV-2 SP - 119510 EP - 119510 JF - Life sciences JO - Life Sci VL - 278 N2 - Currently, the world has been devastated by an unprecedented pandemic in this century. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the agent of coronavirus disease 2019 (COVID-19), has been causing disorders, dysfunction and morphophysiological alterations in multiple organs as the disease evolves. There is a great scientific community effort to obtain a therapy capable of reaching the multiple affected organs in order to contribute for tissue repair and regeneration. In this regard, mesenchymal stem cells (MSCs) have emerged as potential candidates concerning the promotion of beneficial actions at different stages of COVID-19. MSCs are promising due to the observed therapeutic effects in respiratory preclinical models, as well as in cardiac, vascular, renal and nervous system models. Their immunomodulatory properties and secretion of paracrine mediators, such as cytokines, chemokines, growth factors and extracellular vesicles allow for long range tissue modulation and, particularly, blood-brain barrier crossing. This review focuses on SARS-CoV-2 impact to lungs, kidneys, heart, vasculature and central nervous system while discussing promising MSC's therapeutic mechanisms in each tissue. In addition, MSC's therapeutic effects in high-risk groups for COVID-19, such as obese, diabetic and hypertensive patients are also explored. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/33865879/Therapeutic_potential_of_mesenchymal_stem_cells_in_multiple_organs_affected_by_COVID_19_ DB - PRIME DP - Unbound Medicine ER -