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First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode.
Anal Chim Acta. 2021 May 15; 1159:338418.AC

Abstract

Favipiravir, a promising antiviral agent, is undergoing clinical trials for the potential treatment of the novel coronavirus disease 2019 (COVID-19). This is the first report for the electrochemical activity of favipiravir and its electroanalytical sensing. For this purpose, the effect of cationic surfactant, CTAB was demonstrated on the enhanced accumulation of favipiravir at the surface of cathodically pretreated boron-doped diamond (CPT-BDD) electrode. At first, the electrochemical properties of favipiravir were investigated in the surfactant-free solutions by the means of cyclic voltammetry. The compound presented a single oxidation step which is irreversible and adsorption controlled. A systematic study of various operational conditions, such as electrode pretreatment, pH of the supporting electrolyte, concentration of CTAB, accumulation variables, and instrumental parameters on the adsorptive stripping response, was examined using square-wave voltammetry. An oxidation signal at around +1.21 V in Britton-Robinson buffer at pH 8.0 containing 6 × 10-4 M CTAB allowed to the adsorptive stripping voltammetric determination of favipiravir (after 60 s accumulation step at open-circuit condition). The process could be used in the concentration range with two linear segments of 0.01-0.1 μg mL-1 (6.4 × 10-8-6.4 × 10-7 M) and 0.1-20.0 μg mL-1 (6.4 × 10-7-1.3 × 10-4 M). The limit of detection values were found to be 0.0028 μg mL-1 (1.8 × 10-8 M), and 0.023 μg mL-1 (1.5 × 10-7 M) for the first and second segments of calibration graph, respectively. The feasibility of developed methodology was tested to the analysis of the commercial tablet formulations and model human urine samples.

Authors+Show Affiliations

Van Yuzuncu Yil University, Faculty of Science, Department of Biochemistry, 65080, Van, Turkey.Van Yuzuncu Yil University, Faculty of Medicine, Department of Pharmacology, 65080, Van, Turkey.Van Yuzuncu Yil University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080, Van, Turkey. Electronic address: yavuzyardim2002@yahoo.com.Van Yuzuncu Yil University, Faculty of Science, Department of Analytical Chemistry, 65080, Van, Turkey. Electronic address: zuhresenturk@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33867032

Citation

Allahverdiyeva, Shabnam, et al. "First Electrochemical Evaluation of Favipiravir Used as an Antiviral Option in the Treatment of COVID-19: a Study of Its Enhanced Voltammetric Determination in Cationic Surfactant Media Using a Boron-doped Diamond Electrode." Analytica Chimica Acta, vol. 1159, 2021, p. 338418.
Allahverdiyeva S, Yunusoğlu O, Yardım Y, et al. First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode. Anal Chim Acta. 2021;1159:338418.
Allahverdiyeva, S., Yunusoğlu, O., Yardım, Y., & Şentürk, Z. (2021). First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode. Analytica Chimica Acta, 1159, 338418. https://doi.org/10.1016/j.aca.2021.338418
Allahverdiyeva S, et al. First Electrochemical Evaluation of Favipiravir Used as an Antiviral Option in the Treatment of COVID-19: a Study of Its Enhanced Voltammetric Determination in Cationic Surfactant Media Using a Boron-doped Diamond Electrode. Anal Chim Acta. 2021 May 15;1159:338418. PubMed PMID: 33867032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First electrochemical evaluation of favipiravir used as an antiviral option in the treatment of COVID-19: A study of its enhanced voltammetric determination in cationic surfactant media using a boron-doped diamond electrode. AU - Allahverdiyeva,Shabnam, AU - Yunusoğlu,Oruc, AU - Yardım,Yavuz, AU - Şentürk,Zühre, Y1 - 2021/03/18/ PY - 2021/01/09/received PY - 2021/02/20/revised PY - 2021/03/12/accepted PY - 2021/4/19/entrez PY - 2021/4/20/pubmed PY - 2021/4/22/medline KW - Cathodically pretreated boron-doped diamond KW - Cetyltrimethylammonium bromide KW - Favipiravir KW - Real samples KW - Square-wave adsorptive stripping voltammetry SP - 338418 EP - 338418 JF - Analytica chimica acta JO - Anal Chim Acta VL - 1159 N2 - Favipiravir, a promising antiviral agent, is undergoing clinical trials for the potential treatment of the novel coronavirus disease 2019 (COVID-19). This is the first report for the electrochemical activity of favipiravir and its electroanalytical sensing. For this purpose, the effect of cationic surfactant, CTAB was demonstrated on the enhanced accumulation of favipiravir at the surface of cathodically pretreated boron-doped diamond (CPT-BDD) electrode. At first, the electrochemical properties of favipiravir were investigated in the surfactant-free solutions by the means of cyclic voltammetry. The compound presented a single oxidation step which is irreversible and adsorption controlled. A systematic study of various operational conditions, such as electrode pretreatment, pH of the supporting electrolyte, concentration of CTAB, accumulation variables, and instrumental parameters on the adsorptive stripping response, was examined using square-wave voltammetry. An oxidation signal at around +1.21 V in Britton-Robinson buffer at pH 8.0 containing 6 × 10-4 M CTAB allowed to the adsorptive stripping voltammetric determination of favipiravir (after 60 s accumulation step at open-circuit condition). The process could be used in the concentration range with two linear segments of 0.01-0.1 μg mL-1 (6.4 × 10-8-6.4 × 10-7 M) and 0.1-20.0 μg mL-1 (6.4 × 10-7-1.3 × 10-4 M). The limit of detection values were found to be 0.0028 μg mL-1 (1.8 × 10-8 M), and 0.023 μg mL-1 (1.5 × 10-7 M) for the first and second segments of calibration graph, respectively. The feasibility of developed methodology was tested to the analysis of the commercial tablet formulations and model human urine samples. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/33867032/First_electrochemical_evaluation_of_favipiravir_used_as_an_antiviral_option_in_the_treatment_of_COVID_19:_A_study_of_its_enhanced_voltammetric_determination_in_cationic_surfactant_media_using_a_boron_doped_diamond_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(21)00244-0 DB - PRIME DP - Unbound Medicine ER -